Evidence map›Paper›PMID 40829163›Full record

ArticleJournal of medical radiation sciences2025

Planning for Preservation: Feasibility of Erectile Tissue Sparing During Prostate Stereotactic Radiotherapy.

Felicity Hudson, Glen Dinsdale, Tony Young, Anne McMaster, Tania Erven, Olivia Ryan, Sankar Arumugam, Theresa Nguyen, Mark Sidhom

Abstract read
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Article in Journal of medical radiation sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Felicity HudsonLiverpool and Macarthur Cancer Therapy Centres, South Western Sydney Cancer Services, Sydney, New South Wales, Australia.ORCID https://orcid.org/0009-0002-1922-7961
Glen DinsdaleLiverpool and Macarthur Cancer Therapy Centres, South Western Sydney Cancer Services, Sydney, New South Wales, Australia.
Tony YoungLiverpool and Macarthur Cancer Therapy Centres, South Western Sydney Cancer Services, Sydney, New South Wales, Australia.
Anne McMasterLiverpool and Macarthur Cancer Therapy Centres, South Western Sydney Cancer Services, Sydney, New South Wales, Australia.
Tania ErvenLiverpool and Macarthur Cancer Therapy Centres, South Western Sydney Cancer Services, Sydney, New South Wales, Australia.
Olivia RyanLiverpool and Macarthur Cancer Therapy Centres, South Western Sydney Cancer Services, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-5160-6200
Sankar ArumugamLiverpool and Macarthur Cancer Therapy Centres, South Western Sydney Cancer Services, Sydney, New South Wales, Australia.
Theresa NguyenLiverpool and Macarthur Cancer Therapy Centres, South Western Sydney Cancer Services, Sydney, New South Wales, Australia.
Mark SidhomLiverpool and Macarthur Cancer Therapy Centres, South Western Sydney Cancer Services, Sydney, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAn estimated one in six Australian men are diagnosed with prostate cancer (PC) by age 85. Cure and quality of life are the modern definitions of successful cancer treatment, and preservation of continence and sexual function relates closely to treatment outcome satisfaction. Erectile tissue sparing (ETS) is not generally standard practice for PC stereotactic body radiotherapy (SBRT). This retrospective planning study aimed to determine if erectile tissue (ET) could be spared whilst maintaining clinically acceptable doses to target volumes (TV) and critical organs during PC SBRT.

methodsImaging datasets of 30 PC patients treated at our centres were used. Patients underwent magnetic resonance imaging (MRI) scans, with the creation of a substitute CT (sCT) for planning. ET structures, including penile bulb (PB), internal pudendal arteries (IPA) and neurovascular bundles (NVB), were contoured on MRI. Two 40 Gy in five fraction plans were created for each patient, with and without ETS constraints. Plans were compared using Wilcoxon signed-rank tests.

resultsSignificant dose reduction was observed in bilateral IPAs and NVBs using ETS plans. No significant difference was seen in coverage of the clinical TVD

conclusionResults indicate that ETS is feasible in conjunction with a planning MRI during SBRT for PC without compromise to TVs. Further prospective investigation is required to observe whether a decrease in ET dose correlates to a preservation in sexual function and/or improved treatment outcome satisfaction.

Indexed as

Organ Sparing TreatmentsPenile ErectionPenisProstatic NeoplasmsRadiosurgeryRadiotherapy Planning, Computer-AssistedAgedAged, 80 and overFeasibility StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedOrgans at RiskProstateRadiotherapy Dosagemagnetic resonance imagingorgan preservation solutionsprostate cancerquality of lifestereotactic radiation therapy

Identifiers

PMID40829163
PMCPMC12661071

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.