Evidence map›Paper›PMID 40829092›Full record

Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2025

Phase II Study of

Frank I Lin, Jaydira Del Rivero, Jorge A Carrasquillo, Abhishek Jha, Joy Zou, Inna Shamis, Sara Talvacchio, Baris Turkbey, Erich P Huang, Joanna Shih and 10 more

Erratum issuedAbstract readClinical Trial, Phase II
In one paragraph

Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Dual‑targeted radioligand therapy with [European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Pheochromocytomas and Paragangliomas.Endocrinology and metabolism clinics of North America · 2026
    Review
  8. Toward personalized management of metastatic PPGL: decoding the implications of theInternational journal of surgery (London, England) · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Frank I LinMolecular Imaging Branch, National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD.ORCID 0000-0003-3539-1454
Jaydira Del RiveroDevelopmental Therapeutics Branch, National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD.ORCID 0000-0001-9710-4030
Jorge A CarrasquilloMolecular Imaging Branch, National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD.ORCID 0000-0002-8513-5734
Abhishek JhaNational Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.ORCID 0000-0002-1489-2471
Joy ZouMolecular Imaging Branch, National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD.
Inna ShamisMolecular Imaging Branch, National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD.
Sara TalvacchioNational Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.ORCID 0009-0006-6969-4735
Baris TurkbeyMolecular Imaging Branch, National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD.ORCID 0000-0003-0853-6494
Erich P HuangDivision of Cancer Therapy and Diagnosis, Biometric Research Program, National Institutes of Health, National Cancer Institute, Bethesda, MD.
Joanna ShihDivision of Cancer Therapy and Diagnosis, Biometric Research Program, National Institutes of Health, National Cancer Institute, Bethesda, MD.
Joanna Klubo-GwiezdzinskaMetabolic Diseases Branch, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
Esther MenaMolecular Imaging Branch, National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD.
Liza LindenbergMolecular Imaging Branch, National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD.ORCID 0000-0002-8514-0648
Yating TengUniformed Services University of the Health Sciences, Bethesda, MD.ORCID 0000-0001-6568-9783
Freddy E EscorciaMolecular Imaging Branch, National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD.ORCID 0000-0002-0727-3242
Clara ChenDivision of Nuclear Medicine, National Institutes of Health, Clinical Center, Bethesda, MD.
Peter HerscovitchPET Department, National Institutes of Health, Clinical Center, Bethesda, MD.
Corina MilloPET Department, National Institutes of Health, Clinical Center, Bethesda, MD.
Peter L ChoykeMolecular Imaging Branch, National Institutes of Health, National Cancer Institute, Center for Cancer Research, Bethesda, MD.
Karel PacakNational Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.ORCID 0000-0002-3541-3767

Funding

Phase 2 study of Lu-177-DOTATATE in inoperable paraganglioma - pheochromocytoaZIABC011789 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LIN, FRANK · 2017 to 2025
$1.9M
Intramural NIH HHS ZIA BC011789
6 · The paper itself

Abstract

purpose

methodsIn the first stage of this two-stage Simon phase II trial, 36 PPGL patients with RECIST 1.1 progression within 12 months were prospectively recruited into two genetic cohorts (succinate dehydrogenase [

resultsSix-month PFS rate for all patients was 0.861 (95% CI, 0.755 to 0.982), which was significantly lower (

conclusion

Indexed as

Adrenal Gland NeoplasmsOctreotideOrganometallic CompoundsParagangliomaPheochromocytomaRadiopharmaceuticalsAdultAgedBiomarkers, TumorFemaleHumansMaleMiddle AgedProgression-Free SurvivalProspective StudiesBiomarkers, Tumorlutetium Lu 177 dotatateOctreotideOrganometallic CompoundsRadiopharmaceuticals

Identifiers

PMID40829092
PMCPMC12367064

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.