Evidence map›Paper›PMID 40828982›Full record

ArticleJournal of the American Chemical Society2025

Cyanobacteria Join the Kahalalide Conversation: Genome and Metabolite Evidence for Structurally Related Peptides.

Byeol Ryu, Nicole E Avalon, Marine Cuau, Jehad Almaliti, M Omar Din, Caitriona Brennan, Evgenia Glukhov, Rob Knight, Lena Gerwick, William H Gerwick

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Byeol RyuCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-3405-2875
Nicole E AvalonCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0003-3588-892X
Marine CuauCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Jehad AlmalitiCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
M Omar DinDepartment of Pediatrics, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0003-4012-4182
Caitriona BrennanDepartment of Pediatrics, University of California San Diego, La Jolla, California 92093, United States.
Evgenia GlukhovCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Rob KnightDepartment of Pediatrics, University of California San Diego, La Jolla, California 92093, United States.
Lena GerwickCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0001-6108-9000
William H GerwickCenter for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0003-1403-4458

Funding

Unified Computation Tools for Natural Products ResearchR01GM107550 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI COTTRELL, GARRISON W, GERWICK, WILLIAM HENRY · 2013 to 2025
$8.2M
ICBG: "Training, Conservation and Drug Discovery using Panamanian MicroorganismsU01TW006634 · FIC · SMITHSONIAN INSTITUTION · PI GERWICK, WILLIAM HENRY · 2003 to 2013
$7.8M
Screening of US and Jordanian Natural Product Libraries for the Discovery of Blood Brain Barrier (BBB) Penetrant Cathepsin L Inhibitors for the Treatment of Chronic PainR21AT013004 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALMALITI, JEHAD S, GERWICK, WILLIAM HENRY · 2024 to 2024
$342k
A Genomic Approach to Discovering Novel Cathepsin Inhibitors from CyanobacteriaF32AT011475 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AVALON, NICOLE ELIZABETH · 2022 to 2024
$218k
FIC NIH HHS U01 TW006634NCCIH NIH HHS F32 AT011475NCCIH NIH HHS R21 AT013004NIGMS NIH HHS R01 GM107550
6 · The paper itself

Abstract

Kahalalide F is a cyclic depsipeptide with notable anticancer properties, initially discovered from the green alga

Indexed as

CyanobacteriaDepsipeptidesGenome, BacterialMetabolomicsMolecular StructureDepsipeptides

Identifiers

PMID40828982
PMCPMC12449831

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.