Evidence map›Paper›PMID 40828948›Full record

ArticleThe British journal of radiology2025

Intravasation is not only a complication but also a radiological finding for tubal pathologies in hysterosalpingography.

Cemil Gürses, Koray Kaya Kılıç, Alpaslan Yavuz, İclal Erdem Toslak, Ender Uysal, Berkan Sayal, Dilek Yapar

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Article in The British journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Cemil GürsesDepartment of Radiology, University of Health Sciences, Antalya Training and Research Hospital, Antalya, 07050, Turkey.ORCID 0000-0003-2931-9309
Koray Kaya KılıçDepartment of Radiology, University of Health Sciences, Antalya Training and Research Hospital, Antalya, 07050, Turkey.ORCID 0000-0002-2750-8205
Alpaslan YavuzDepartment of Radiology, University of Health Sciences, Antalya Training and Research Hospital, Antalya, 07050, Turkey.ORCID 0000-0002-8796-988X
İclal Erdem ToslakDepartment of Radiology, University of Health Sciences, Antalya Training and Research Hospital, Antalya, 07050, Turkey.ORCID 0000-0002-1947-8341
Ender UysalDepartment of Radiology, University of Health Sciences, Antalya Training and Research Hospital, Antalya, 07050, Turkey.ORCID 0000-0002-0450-7496
Berkan SayalPerinatology, University of Health Sciences, Antalya Training and Research Hospital, Antalya, 07050, Turkey.ORCID 0000-0002-9144-3047
Dilek YaparTurkish Ministry of Health, Muratpasa District Health Directorate, Antalya, 07050, Turkey.ORCID 0000-0001-7656-1152

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesHysterosalpingography (HSG) remains the first-line imaging technique for assessing fallopian tube conditions due to its accessibility, cost-effectiveness, and high diagnostic accuracy. Intravasation, the leakage of contrast media into myometrial or vascular structures during HSG, has been documented as a complication. This study aimed to determine the prevalence of intravasation, explore the relationship between intravasation and tubal occlusion, and assess the applicability of grading intravasation.

methodsA retrospective analysis of 3032 HSG examinations performed between January 2021 and May 2024 was conducted. Intravasation, tubal occlusion, and related findings were recorded using standard X-ray equipment and categorized prospectively. Statistical analysis included logistic regression to identify predictors of tubal occlusion and inter-observer agreement using Fleiss Kappa. Diagnostic metrics for intravasation as a radiological marker of tubal occlusion were calculated.

resultsIntravasation was observed in 2.6% of cases. Among cases with tubal occlusion, 16.4% exhibited intravasation. The sensitivity, specificity, positive predictive value, and negative predictive value of intravasation for detecting tubal occlusion were 14.5%, 99.8%, 92.3%, and 85.6%, respectively. Adjusted odds ratios indicated that intravasation increased the likelihood of tubal occlusion approximately 55-fold. Inter-observer agreement for intravasation detection was almost perfect (Kappa = 0.97). Limitations included the absence of oil-based contrast and a pressure manometer during contrast infusion.

conclusionsIntravasation, traditionally viewed as a complication, emerges as a significant radiological indicator of tubal occlusion. Incorporating intravasation characteristics, such as initiation time, into grading systems may enhance diagnostic accuracy. Further refinement of classification systems and broader clinical validation are recommended. ADVANCES IN KNOWLEDGE: About 92.3% of tubes with intravasation were occluded and the site of intravasation correlated with the occlusion site. Occlusion was 55× more likely in cases with intravasation, traditionally viewed as a complication, emerges as a significant radiological indicator of tubal occlusion.

Indexed as

Contrast MediaExtravasation of Diagnostic and Therapeutic MaterialsFallopian Tube DiseasesHysterosalpingographyAdultFallopian TubesFemaleHumansMiddle AgedRetrospective StudiesSensitivity and SpecificityContrast Mediahysterosalpingographyinfertilityocclusiontubal

Identifiers

PMID40828948
PMCPMC12810878

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