ArticleJournal of the American Chemical Society2025
Cobalt(0)-Catalyzed Isomerization of Allylamines Promoted by Monodentate Benzofuran Phosphines.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Regio- and Enantioselective Alkoxycarbonylation of Unactivated Terminal Alkenes under Palladium-Bromide-Monophosphine Catalysis.Journal of the American Chemical Society · 2026Article
- 1,2-Bis[di-(benzo-furan-2-yl)phosphan-yl]ethane.IUCrData · 2025Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Isomerization of C-C double bonds is an efficient tool for converting bulk olefins into high-value compounds. Herein we describe a newly developed homogeneous cobalt-based system which enables the isomerization of allylamines to enamines with similar activity and selectivity to noble metal catalysts. The catalyst activity was bound to the presence of furan-2-yl substituents of the phosphine ligand, while the selectivity was increased with the number of benzofuran-2-yl groups. The resulting cobalt(0) catalysts allowed the isomerization of various aliphatic and aromatic allylamines, including the synthesis of industry-relevant products with high catalytic activity. Potential industrial application of our system was substantiated by the scale-up experiment, which provided 311 g of citronellal in 96% yield. We proposed a plausible mechanism based on EPR and NMR analysis combined with deuterium labeling, radical trapping experiments, and kinetic studies.
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