Observational studyThe journals of gerontology. Series A, Biological sciences and medical sciences2025
The INSPIRE-T longitudinal observational study centered on intrinsic capacity: baseline data.
Observational study in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Cross-sectional associations of loneliness with plasma p-tau217 and neurofilament light chain in dementia-free older adults in the INSPIRE-T baseline cohort.Journal of Alzheimer's disease : JAD · 2026Article
- Association between oral frailty and locomotive syndrome among community-dwelling older adults.BMC oral health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThe "INStitute for Prevention," "healthy agIng," and "medicine REjuvenative" "Translational" (INSPIRE-T) study is a 10-year observational study. The primary objective of which is to study trajectories of aging across lifespan from the perspective of intrinsic capacity (IC) through deep clinical and biological phenotyping.
methodsIC was assessed in the INSPIRE-T cohort stratified by age (10-year age groups) using the World Health Organization (WHO) integrated care for older people (ICOPE) program. Biospecimens (biofluids, dental plaque, nasopharyngeal swabs, stools, hair follicles, and skin biopsies) were also collected for biomarker studies and drug-target identification for the prediction and prevention of IC declines respectively.
resultsThe INSPIRE-T baseline data is presented including demographic, health, anthropometric, lifestyle, and IC characteristics of the cohort. The open cohort (ongoing recruitment) currently consists of 1109 participants with data available at baseline (61.9% female) aged from 20 to 102 years old (mean age ± standard deviation: 62.4 ± 19.0 years). The most prevalent IC abnormalities identified using ICOPE Step 1. screening appeared to be in vision (89.3%), audition (30.5%), and cognition (24.7%) in the total baseline population, while locomotor capacity abnormalities (5.4%) appeared to be the least frequent. Sex-specific differences were observed for the domains of psychological well-being, audition, vitality in 30-39-year olds and vision in subjects ≤39 years old.
conclusionsThe ultimate goal of INSPIRE-T is to enable the identification of individuals at risk of IC declines in order to implement personalized preventive interventions to promote healthy aging.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.