Evidence map›Paper›PMID 40828811›Full record

ArticleDiabetes care2025

Longitudinal Continuous Glucose Monitoring Study in Young Children With Presymptomatic Type 1 Diabetes Followed in the Environmental Determinants of Islet Autoimmunity (ENDIA) At-Risk Cohort Study.

Aveni Haynes, Grant J Smith, Alexandra Tully, Brydie-Rose Mellor, Megan A S Penno, Maria E Craig, John M Wentworth, Tony Huynh, Peter G Colman, Georgia Soldatos and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Aveni HaynesChildren's Diabetes Centre, The Kids Research Institute Australia, Nedlands, Western Australia, Australia.ORCID 0000-0001-9954-5016
Grant J SmithChildren's Diabetes Centre, The Kids Research Institute Australia, Nedlands, Western Australia, Australia.
Alexandra TullyChildren's Diabetes Centre, The Kids Research Institute Australia, Nedlands, Western Australia, Australia.
Brydie-Rose MellorChildren's Diabetes Centre, The Kids Research Institute Australia, Nedlands, Western Australia, Australia.
Megan A S PennoFaculty of Health and Medical Sciences and Robinson Research Institute, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0002-9617-0826
Maria E CraigSchool of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0001-6004-576X
John M WentworthDepartment of Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Tony HuynhDepartment of Endocrinology and Diabetes, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
Peter G ColmanDepartment of Diabetes and Endocrinology, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Georgia SoldatosMonash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Amanda J AndersonFaculty of Health and Medical Sciences and Robinson Research Institute, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Kelly J McGormFaculty of Health and Medical Sciences and Robinson Research Institute, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.
Jennifer J CouperFaculty of Health and Medical Sciences and Robinson Research Institute, Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0003-4448-8629
Elizabeth A DavisChildren's Diabetes Centre, The Kids Research Institute Australia, Nedlands, Western Australia, Australia.ORCID 0000-0003-4244-5473
Environmental Determinants of Islet Autoimmunity (ENDIA) Study Group

Funding

Australasian Paediatric Endocrinology GroupDiabetes Research Western AustraliaJuvenile Diabetes Research Foundation International 3-PDF-2020-939-A-NRaine Medical Research FoundationThe Leona M. and Harry B. Helmsley Charitable Trust 2205-05241Women and Childrenșs Hospital Research Foundation
6 · The paper itself

Abstract

objectiveTo characterize longitudinal continuous glucose monitoring (CGM) data in young children with presymptomatic type 1 diabetes. RESEARCH DESIGN AND

methodsBetween 2021 and 2024, children in the Australian ENDIA study with persistent multiple islet autoimmunity underwent blinded CGM assessments every 3-6 months. CGM-derived metrics (SD sensor glucose, coefficient of variation, mean sensor glucose, and percent CGM time >7.8 mmol/L [140 mg/dL]) were determined for each child by time from islet autoantibody detection.

resultsA total of 178 CGM assessments were analyzed for 36 children (median [Q1, Q3] age at first assessment 4.5 [3.5, 6.0] years) who underwent a median of 5.5 (2.0, 7.0) assessments of 11 (9, 15) days duration each. High within-person variability was observed in serial CGM metrics, including percent CGM time >7.8 mmol/L (140 mg/dL) (intraclass correlation coefficient 0.30).

conclusionsFurther research is needed to inform interpretation of CGM-derived metrics in young children with presymptomatic type 1 diabetes.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 1Islets of LangerhansAustraliaAutoimmunityBlood Glucose Self-MonitoringChildChild, PreschoolContinuous Glucose MonitoringFemaleHumansLongitudinal StudiesMaleBlood Glucose

Identifiers

PMID40828811
PMCPMC12451827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.