Trial reportPloS one2025
Randomized controlled trial of stress management and resiliency training for depression (SMART-D)-pilot study.
Trial report in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04388748 (Randomized Controlled Trial of Stress Management and Resiliency Training for Depression), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Controlled Trial of Stress Management and Resiliency Training for Depression (SMART-D) vs Treatment as Usual in the Treatment of Major Depression
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveMajor Depressive Disorder (MDD) is characterized by high stress sensitivity and unsatisfactory response rates to standard treatments. Stress and depression share a bidirectional relationship. We, therefore, conducted a pilot randomized control trial (RCT) to understand if adjunctive stress management and resiliency training tailored for depression(SMART-D), can improve treatment outcomes in patients with MDD, receiving treatment as usual(TAU) with standard treatments (medications and/or psychotherapy), in real-world clinical settings, compared to a group receiving TAU.
methodsParticipants with MDD, in a current depressive episode, were randomized to adjunctive SMART-D (delivered by video telehealth over 8 weeks), compared to TAU alone. Random assignment, blinding of raters and statistician were utilized. The primary outcome measure was baseline to end point change in depression [Hamilton Rating Scale for Depression (HAM-D] over a 6-month follow-up period using a mixed model regression analysis.
results27 participants (mean age 47.9 ± 14 years, female 67%) enrolled in the study (TAU = 14, SMART-D + TAU = 13). Baseline mood ratings were in mild-moderate symptom severity (HAM-D)- SMART-D + TAU = 12.2 ± 6.6, TAU = 13.9 ± 5.7). Linear mixed model analysis showed significant Group*Time interaction for measures of depression (HAM-D) (B = 6.1 (CI = 1.5-10.8, P = .01) and perceived stress (PSS) (B = 5.5(0.5-10.6), p = .03) between the 2 groups at 3 months post follow-up ((HAMD)-SMART-D + TAU = 8.7 ± 4.3 Vs. TAU = 16.1 ± 6.3), but not at 6-months (SMART-D + TAU = 8.1 ± 5.4 Vs. TAU = 12.3 ± 5.5).
conclusionsA RCT of 27 adults with MDD provide initial support that an adjunctive resiliency intervention (SMART-D) for patients with MDD may positively impact symptoms of depression and perceived stress, earlier than standard care. A small sample size limits ability to draw firm conclusions. Further investigation is warranted, using larger samples. Clinical Trials Registration I.D.# NCT04388748.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.