SynthesisPLoS neglected tropical diseases2025
Transmission models of Mycobacterium ulcerans: A systematic review.
Synthesis in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Current Status and Perspectives of Antibacterial Agents Belonging to 2-Oxazolidinones.Pharmaceuticals (Basel, Switzerland) · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
backgroundBuruli ulcer, caused by Mycobacterium ulcerans, is a neglected tropical disease affecting 33 countries worldwide. Elucidating the full transmission pathways of this infection remains an important active field of investigation, especially in Central and West Africa and Southeast Australia in the state of Victoria where disease burden is high. This systematic review (pre-registered on PROSPERO: CRD42023452944) provides an overview of mathematical transmission models of M. ulcerans and highlights future areas of investigation crucial to understanding transmission of Buruli ulcer and quantifying the impact of potential preventative interventions. METHODOLOGY/PRINCIPAL
findingsWe searched Scopus, PubMed, Embase and CAB abstracts on January [Formula: see text] 2025, and included studies which reported novel mechanistic models of M. ulcerans transmission. We qualitatively compared mathematical model structures, parameterisation methods, model analyses and author conclusions, and conducted a quality assessment of the studies using a modified Philips checklist. Twenty studies met the inclusion criteria; 18 performed theoretical analyses, while only five validated their model against empirical data, limiting conclusions and the implications for disease management. Seventeen studies focused on a water bug/fish/human system proposed for Central and West Africa with a diverse ranges of model structures. Three models described the mosquito/possum system of Southeast Australia using similar models, with none considering human populations. CONCLUSIONS/SIGNIFICANCE: This review highlights a large gap in modelling Buruli ulcer in Victoria: there are currently no models of this system that have been specifically formulated with data. Such models could be valuable for exploring and testing likely transmission scenarios. Future research should focus on developing models that incorporate local data and consider all potential transmission pathways to better understand the disease dynamics and evaluate potential interventions.
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Registered trials
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