ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2025
Sodium intake and biological sex influence urinary endothelin-1 in salt-resistant adults: a pilot study.
Victoria L Nasci, Jazmine I Benjamin, Rebecca C Fetter, Joseph M Stock, Nathan T Romberger, Joseph C Watso, Matthew C Babcock, Megan M Wenner, Austin T Robinson, Eman Y Gohar
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In one paragraphArticle in American journal of physiology. Regulatory, integrative and comparative physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
10 authors.
Victoria L NasciDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0002-1891-8974 Jazmine I BenjaminDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Rebecca C FetterDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.
Joseph M StockDepartment of Kinesiology, East Carolina University, Greenville, North Carolina, United States.ORCID 0000-0002-9866-415X Nathan T RombergerDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, United States.ORCID 0000-0002-8470-4069 Joseph C WatsoCardiovascular and Applied Physiology Laboratory, Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, Florida, United States.ORCID 0000-0001-7840-0643 Matthew C BabcockDivision of Geriatric Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.ORCID 0000-0002-8047-4411 Megan M WennerDepartment of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware, United States.ORCID 0000-0003-0055-783X Austin T RobinsonDepartment of Kinesiology, Indiana University Bloomington, Bloomington, Indiana, United States.ORCID 0000-0001-8250-3952 Eman Y GoharDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States.ORCID 0000-0003-0988-6445 Funding
Vascular Consequences of Duchenne Muscular DystrophyP20GM113125 · NIGMS · UNIVERSITY OF DELAWARE · PI EDWARDS, DAVID G · 2016 to 2025
$23.3MSuppression of ERalpha in Hematopoietic Stem Cell-Derived Adipocytes Increases Adiposity via Kynurenine and the Aryl Hydrocarbon ReceptorU54AG062319 · NIA · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 2018 to 2026
$13.5MVANDERBILT NEPHROLOGY TRAINING PROGRAMT32DK007569 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRIS, RAYMOND C., IKIZLER, TALAT ALP · 1988 to 2024
$5.8MAdverse Neurogenic Actions of Dietary SaltR01HL128388 · NHLBI · UNIVERSITY OF DELAWARE · PI FARQUHAR, WILLIAM B, STOCKER, SEAN D · 2016 to 2019
$2.6MUnraveling the Impact of Estrogen Signaling on Postmenopausal HypertensionR01HL171122 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eman Gohar · 2024 to 2026
$1.8MSex Differences in Renal Sodium HandlingR00DK119413 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOHAR, EMAN · 2021 to 2023
$740kRacial Differences in Serum Sodium and Blood Pressure RegulationK01HL147998 · NHLBI · TRUSTEES OF INDIANA UNIVERSITY · PI ROBINSON, AUSTIN TYLER · 2019 to 2023
$705kTime-Efficient Inspiratory Muscle Strength Training as a New Approach to Lower Blood Pressure, Improve Respiratory Function, and Reduce Exertional Dyspnea in Adults with ObesityK01HL160772 · NHLBI · FLORIDA STATE UNIVERSITY · PI Joseph Watso · 2022 to 2026
$693kNeural and Renal Contributions to Hypertension with Androgen Deprivation TherapyK01HL164978 · NHLBI · VIRGINIA COMMONWEALTH UNIVERSITY · PI Matthew C Babcock · 2023 to 2026
$665kDietary Ketone Supplementation as a Novel Strategy to Attenuate the Adverse Vascular and Renal Consequences of High Dietary Salt in Older AdultsR21AG087524 · NIA · TRUSTEES OF INDIANA UNIVERSITY · PI ROBINSON, AUSTIN TYLER · 2024 to 2025
$454kSex Differences in Central Neural Activation During Acute HypernatremiaF31HL170563 · NHLBI · UNIVERSITY OF DELAWARE · PI ROMBERGER, NATHAN · 2023 to 2024
$63kAmerican Heart Association (AHA) 23CDA1037938HHS | National Institutes of Health (NIH) P20GM113125HHS | National Institutes of Health (NIH) R01HL128388HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31HL170563HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K01HL147998HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K01HL160772HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K01HL164978HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL171122HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R00DK119413HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) T32DK007569HHS | NIH | National Institute on Aging (NIA) R21AG087524HHS | NIH | National Institute on Aging (NIA) U54AG062319NHLBI NIH HHS F31 HL170563NHLBI NIH HHS K01 HL147998NHLBI NIH HHS K01 HL160772NHLBI NIH HHS K01 HL164978NHLBI NIH HHS R01 HL128388NHLBI NIH HHS R01 HL171122NIA NIH HHS R21 AG087524NIA NIH HHS U54 AG062319NIDDK NIH HHS R00 DK119413NIDDK NIH HHS T32 DK007569NIGMS NIH HHS P20 GM113125
6 · The paper itselfAbstract
Hypertension is more prevalent in males than age-matched premenopausal females. Average sodium intake in the United States is higher than recommended and is a risk factor for developing hypertension. Sex differences in renal sodium homeostasis may underlie sex differences in hypertension prevalence. For example, renal endothelin-1 (ET-1) plays a key role in the maintenance of blood pressure and sodium homeostasis. Previous rodent studies demonstrate that females excrete higher urinary ET-1 compared with males, and increasing dietary sodium promotes urinary ET-1 excretion only in male rats. However, the impact of sex on sodium and renal ET-1 signaling in humans is unclear. Therefore, we aimed to determine whether the renal ET-1 system responds differently to salt loading in male and female human research participants. To test our hypothesis, normotensive salt-resistant male and female participants were administered a low (1 g/day), recommended (2.3 g/day), and high (7 g/day) sodium diet for 10 days each in random order. The 24-h urine samples were collected and assessed for sodium and ET-1. Following increased dietary sodium, both males and females increased urinary sodium excretion (diet:
Indexed as
Endothelin-1HypertensionKidneySodium Chloride, DietarySodium, DietaryAdultBlood PressureFemaleHumansMaleMiddle AgedPilot ProjectsRenal EliminationSex FactorsSodiumYoung AdultEndothelin-1SodiumSodium Chloride, DietarySodium, Dietaryblood pressurenatriuresissaltsalt-resistancesex
Identifiers
PMID40828571
PMCPMC12418720
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