Trial reportJournal of acquired immune deficiency syndromes (1999)2025
Randomized Controlled Trial of a HIV Prevention App to Increase Pre-exposure Prophylaxis Uptake Among Gay and Bisexual Men Who Have Sex With Men in the United States: The HealthMindr PrEP Study.
Trial report in Journal of acquired immune deficiency syndromes (1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- Preferences for mHealth Features to Support Engagement in the HIV Preexposure Prophylaxis Cascade Among Men Who Have Sex With Men in Peru: Cross-Sectional Online Survey.JMIR public health and surveillance · 2026Article
- Identifying Implementation Gaps in the HIV Prevention Cascade among Peruvian Men Who Have Sex with Men.AIDS and behavior · 2026Article
- Integrating Mobile Text Messaging Pre-Exposure Prophylaxis Navigation Services Into a Home HIV and Sexually Transmitted Infection Self-Testing Program in the United States: Formative Work and Pilot Implementation Study.JMIR formative research · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundWe tested an adaptation of a mobile HIV prevention smartphone app, HealthMindr-PrEP, to assess its effectiveness to increase pre-exposure prophylaxis (PrEP) uptake among gay and bisexual men who have sex with men.
settingThis study was conducted online among gay and bisexual men who have sex with men living in Ending the HIV Epidemic priority jurisdictions, primarily in the southern United States.
methodsWe conducted a randomized controlled trial in which participants were randomly assigned to receive the intervention app or an app that only allowed participants to track their study progress. The primary outcome was self-reported PrEP uptake. Cox proportional hazards models were used to compare the rate of PrEP uptake across study arms.
resultsAlthough no results were statistically significant, the rate of PrEP initiation was higher among participants in the intervention arm compared with the control arm, particularly among participants with PrEP indications at baseline. Among those with PrEP indications at baseline, participants in the intervention arm had a 64% higher rate of PrEP initiation compared with the control arm (hazard ratio = 1.64, 95% CI: 0.89 to 3.03). Among those without PrEP indications, the same hazard ratio was 1.05 (95% CI: 0.67 to 1.66).
conclusionsOur results suggest that HealthMindr-PrEP increases the rate of PrEP uptake compared with a standard of care control condition; however, we had insufficient statistical power for stratified analyses that demonstrated that the strongest effect was among those who had PrEP indications at baseline.
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