Evidence map›Paper›PMID 40828527›Full record

ArticleTranslational vision science & technology2025

A Novel System for Measuring Eyeball Rotation Angle Based on Color Fundus Photographs in Natural Head Position.

Cheng Wan, Xiaoxuan Lv, Xinya Hu, Yang Yang, Weihua Yang

Abstract read
In one paragraph

Article in Translational vision science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cheng WanCollege of Electronic and Information Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, People's Republic of China.
Xiaoxuan LvCollege of Electronic and Information Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, People's Republic of China.
Xinya HuShenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, People's Republic of China.
Yang YangCollege of Electronic and Information Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, People's Republic of China.
Weihua YangShenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, Shenzhen, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study presents an artificial intelligence (AI)-based system for measuring eyeball rotation angles, which is a key symptom in assessing eye disease severity. The system aims to accurately segment the optic disc and macula, and compute the eyeball rotation angle based on these features. Methods: The system consists of three modules: optic disc segmentation, macular segmentation, and measurement. The optic disc segmentation module utilizes the Efficient-UNet3+ network to address sample imbalance and irregular edge detection of the optic disc. The macular segmentation module uses the Efficient-UNet based on Dual Attention network (DA-EUNet) to enhance macular recognition and boundary feature detection while suppressing irrelevant background interference. The measurement module calculates the eyeball rotation angle by locating the centers of the optic disc and macula and determining the angle between the line connecting these centers and the horizontal vector. Results: The proposed method demonstrated high accuracy, with a correlation coefficient of 0.94 compared to expert measurements. Statistical analysis revealed no significant difference between the AI-based measurements and expert assessments (P = 0.26). Conclusions: This system achieves high accuracy and reliability in clinical diagnostics. The segmentation techniques used significantly improve feature recognition and segmentation performance, enabling accurate measurements of eyeball rotation. Translational Relevance: This AI-based system bridges the gap between basic research in medical image processing and clinical care. It provides an automated and reliable tool for ophthalmologists to assess eyeball rotation, which is crucial for diagnosing eye diseases. Eyeball rotation can occur in many eye diseases or systemic diseases, and measuring the eyeball rotation angle has been a challenging issue in clinical practice. By automating this process, the system reduces the clinicians' workload and enhances diagnostic consistency.

Indexed as

Artificial IntelligenceDiagnostic Techniques, OphthalmologicalOptic DiskPhotographyFundus OculiHumansMacula LuteaReproducibility of ResultsRotation

Identifiers

PMID40828527
PMCPMC12369904

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.