Evidence map›Paper›PMID 40828491›Full record

ArticleJournal of nephrology2025

Trust in physicians as a mediator of the relationship between person-centered care and medication adherence in patients undergoing hemodialysis: a cross-sectional study.

Yusuke Kanakubo, Ryohei Inanaga, Tatsunori Toida, Tetsuro Aita, Mamiko Ukai, Atsuro Kawaji, Takumi Toishi, Masatoshi Matsunami, Yu Munakata, Tomo Suzuki and 2 more

Erratum issuedAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yusuke KanakuboTessyoukai Kameda Family Clinic Tateyama, Tateyama, Chiba, Japan.
Ryohei InanagaDepartment of Nephrology, Shin-Yurigaoka General Hospital, Kawasaki, Kanagawa, Japan.
Tatsunori ToidaDepartment of Clinical Epidemiology, Graduate School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
Tetsuro AitaDepartment of Clinical Epidemiology, Graduate School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
Mamiko UkaiTessyoukai Kameda Family Clinic Tateyama, Tateyama, Chiba, Japan.
Atsuro KawajiDepartment of Nephrology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Takumi ToishiDepartment of Nephrology, Kameda Medical Center, Kamogawa, Chiba, Japan.
Masatoshi MatsunamiDepartment of Clinical Epidemiology, Graduate School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
Yu MunakataChikuseikai Munakata Clinic, Shinjuku-ku, Tokyo, Japan.
Tomo SuzukiDepartment of Clinical Epidemiology, Graduate School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.
Tadao OkadaTessyoukai Kameda Family Clinic Tateyama, Tateyama, Chiba, Japan.
Noriaki KuritaDepartment of Clinical Epidemiology, Graduate School of Medicine, Fukushima Medical University, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan. kuritanoriaki@gmail.com.ORCID http://orcid.org/0000-0003-4127-7500

Funding

Japan Society for the Promotion of Science JP19KT0021Japan Society for the Promotion of Science JP22K19690Japan Society for the Promotion of Science JP23K16271
6 · The paper itself

Abstract

backgroundPerson-centered care and trust in physicians influence medication adherence among dialysis patients. However, the mechanisms linking person-centered care to medication adherence, particularly the mediating effect of trust in physicians, remain unclear. This study investigated the interrelationships between person-centered care, trust in physicians, and medication adherence.

methodsUsing a multicenter cross-sectional study of Japanese adults receiving outpatient hemodialysis at six dialysis centers, person-centered care was assessed using the 13-item Japanese Primary Care Assessment Tool-Short Form (JPCAT-SF), which included longitudinality and care coordination. Trust in physicians was measured using the five-item Wake Forest Physician Trust Scale. Medication adherence was measured using the 12-item Adherence Starts Knowledge (ASK-12) scale. General linear models examined person-centered care, physician trust, and medication adherence relationships. Mediation analysis determined how much trust in physicians mediated the person-centered care-medication adherence relationship.

resultsA total of 483 patients, with median age and dialysis vintage of 71.9 and 5.7 years, respectively, were included in the analysis. High-quality person-centered care was associated with lower barriers to medication adherence in a dose-response manner across JPCAT-SF quartiles compared to no usual source of care. Trust in physicians partially mediated this relationship in a dose-response pattern, with the proportion of the indirect effect increasing from 16.1% (95% CI 4.5-33.8%) in Q2 to 33.3% (95% CI 17.4-65.5%) in Q4. Similar findings were observed for person-centered care subdomains.

conclusionsHigh-quality person-centered care was associated with medication adherence, with trust in physicians playing a key mediating role. Strategies to enhance medication adherence in hemodialysis patients should incorporate multidimensional person-centered care approaches, building trust and strengthening continuity and care coordination.

Indexed as

Medication AdherencePatient-Centered CarePhysician-Patient RelationsRenal DialysisTrustAgedAged, 80 and overCross-Sectional StudiesFemaleHumansJapanMaleMiddle AgedMedication adherencePerson-centered careTrust

Identifiers

PMID40828491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.