ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2025
Oscillatory Dynamics Serving Verbal Working Memory Differ in People with HIV and Are Linked To Disease Duration.
Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Elevated inflammation in people with HIV is associated with aberrant neural oscillations serving selective attention.Journal of neuroinflammation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundMedical advances have greatly improved the quality of life and extended the longevity of people with HIV (PWH). However, many PWH still develop neurocognitive deficits even in the presence of effective viral suppression, with impairments in verbal working memory (VWM) being among the most common. While previous neuroimaging studies have demonstrated altered neural responses during VWM, the underlying temporal dynamics and their relation to clinical indices of HIV remain poorly understood. HYPOTHESIS: PWH will have altered neural oscillatory dynamics in brain regions supporting VWM compared to controls, above and beyond the effect of age, and these oscillatory differences will scale with clinical indices of HIV.
methods166 participants (77 virally-suppressed PWH, 89 demographically-matched controls) completed a VWM task during magnetoencephalography, which was separated into encoding and maintenance phases. Whole-brain, mixed-model ANCOVAs were performed to assess the effects of HIV status on neural dynamics controlling for age.
resultsPWH performed significantly worse on the task compared to controls. During encoding, there was a significant interaction of group-by-time window, such that PWH had significantly weaker alpha/beta oscillations in the left inferior frontal, superior temporal, and anterior cingulate relative to controls. Further, weaker activity in the anterior cingulate scaled with increased disease duration. PWH also displayed weaker alpha/beta oscillations during maintenance in frontal, temporal, parietal, anterior cingulate, and cerebellar cortices.
conclusionsPWH exhibited weaker task-related oscillatory activity during VWM, which was associated with disease duration in the anterior cingulate. Overall, these findings suggest that HIV modulates the neural dynamics underlying VWM, with progressive effects in some areas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.