ArticleJournal of the American Chemical Society2025
Migrating Group Strategy for Remote Functionalization of Seven-Membered Rings.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Intermolecular Selective 1,2-Aminohydroxylation of 1,3-Dienes Enabled by Palladium/Copper/Oxygen Cooperation.Precision chemistry · 2026Article
- 1,2-Migration of oxamoyl-protected alcohols via reversible C-H sampling.National science review · 2026Article
- Radical Sampling Enabled Saturated N-Heterocycle Cyclization.Journal of the American Chemical Society · 2026Article
- Article
- Nickel-Catalyzed cine-Substitution Toward Carbonyl Dance.Chemistry, an Asian journal · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Seven-membered rings are essential structural components in bioactive compounds, yet their precise synthesis remains challenging compared to smaller ring systems. While traditional approaches rely on ring assembly strategies, direct functionalization of simpler cyclic precursors offers an attractive alternative to substituted building blocks. We report a photocatalytic transannular ketone migration strategy that converts 1,1-disubstituted acylcycloheptanes into 1,4-disubstituted products under mild conditions, promoted by sodium decatungstate and thiol cocatalysts under light-emitting diode (LED) irradiation. The process operates via reversible hydrogen atom abstraction and donation at multiple sites within the ring, followed by site-selective migration via radical addition and β-scission at the exocyclic carbonyl group. This dynamic kinetic approach to site-selective C-H functionalization provides regioselective access to densely substituted seven-membered rings, addressing a longstanding gap in synthetic methodology.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.