Evidence map›Paper›PMID 40828403›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025

Association of predominant peripheral lesions with retinal microvasculature and risk of vitreous hemorrhage in proliferative diabetic retinopathy.

Jenny Gan, Xinyi Ding, Ioanna Ploumi, Francesco Romano, Katherine M Overbey, Mauricio D Garcia, Itika Garg, Filippos Vingopoulos, Isabella Stettler, Matthew J Finn and 8 more

Abstract read
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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jenny Gan *Harvard Retinal Imaging Lab, Boston, MA, USA.
Xinyi Ding *Harvard Retinal Imaging Lab, Boston, MA, USA.
Ioanna PloumiHarvard Retinal Imaging Lab, Boston, MA, USA.
Francesco RomanoHarvard Retinal Imaging Lab, Boston, MA, USA.
Katherine M OverbeyHarvard Retinal Imaging Lab, Boston, MA, USA.
Mauricio D GarciaHarvard Retinal Imaging Lab, Boston, MA, USA.
Itika GargHarvard Retinal Imaging Lab, Boston, MA, USA.
Filippos VingopoulosHarvard Retinal Imaging Lab, Boston, MA, USA.
Isabella StettlerHarvard Retinal Imaging Lab, Boston, MA, USA.
Matthew J FinnHarvard Retinal Imaging Lab, Boston, MA, USA.
Peyman RazaviHarvard Retinal Imaging Lab, Boston, MA, USA.
Jocelyn M RodriguezHarvard Retinal Imaging Lab, Boston, MA, USA.
Cade F BennettHarvard Retinal Imaging Lab, Boston, MA, USA.
Nimesh A PatelRetina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA.
Leo A KimRetina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA.
Deeba HusainRetina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA.
Demetrios G VavvasRetina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA, 02114, USA.
John B MillerHarvard Retinal Imaging Lab, Boston, MA, USA. john_miller@meei.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study examines the association between predominant peripheral lesions (PPL) and retinal microvasculature with the short-term risk of vitreous hemorrhage (VH) in eyes with proliferative diabetic retinopathy (PDR).

methodsA total of 111 PDR eyes from 84 patients with the same day Ultra-widefield Color Fundus Photography (Optos) and Swept-source Optical Coherence Tomography Angiograms (PLEX

resultsPPL were identified in 36 out of 111 eyes (32.4%). OCTA parameters didn't show significant differences in groups with or without PPL. Over a period of 16.4 ± 11.0 months, VH occurred in 23 eyes, 14 with a history of VH and 9 without. A significant association was found between PPL presence and new VH occurrence (p = 0.028) but not for recurrent VH (P > 0.05). The extent of PPL was a significant predictor for the new VH, after adjustments for age, DM duration and prior anti-vascular endothelial growth factor (anti-VEGF) and panretinal photocoagulation (PRP) treatment (HR = 1.92, p = 0.03, 95% CI [1.06-3.50]).

conclusionCenter and posterior OCTA metrics are comparable in eyes with or without PPL, but PPL is associated with VH development. Advancements in UWF imaging technologies may lead to the development of a new DR grading scheme to predict VH risk in patients with PDR.

Indexed as

Diabetic RetinopathyMicrovesselsRetinal VesselsTomography, Optical CoherenceVitreous HemorrhageAgedFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHumansMaleMiddle AgedProspective StudiesRetrospective StudiesRisk FactorsPredominantly peripheral lesionsProliferative diabetic retinopathyVitreous hemorrhage

Identifiers

PMID40828403

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.