Evidence map›Paper›PMID 40828341›Full record

Observational studyEuropean journal of pediatrics2025

Surfactant treatment rate in very premature infants following change to less-invasive surfactant administration.

Diane Gillot, Christophe Milési, Clémentine Combes, Vincent Brodeau, Arthur Gavotto, Gilles Cambonie

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Diane GillotDepartment of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service, Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier, 371 Avenue du Doyen Gaston Giraud, Cedex 5, 34295, Montpellier, France.
Christophe MilésiDepartment of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service, Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier, 371 Avenue du Doyen Gaston Giraud, Cedex 5, 34295, Montpellier, France.
Clémentine CombesDepartment of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service, Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier, 371 Avenue du Doyen Gaston Giraud, Cedex 5, 34295, Montpellier, France.
Vincent BrodeauDepartment of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service, Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier, 371 Avenue du Doyen Gaston Giraud, Cedex 5, 34295, Montpellier, France.
Arthur GavottoDepartment of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service, Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier, 371 Avenue du Doyen Gaston Giraud, Cedex 5, 34295, Montpellier, France.
Gilles CambonieDepartment of Neonatal Medicine, Pediatric Intensive Care and Pediatric Emergency Transport Service, Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier, 371 Avenue du Doyen Gaston Giraud, Cedex 5, 34295, Montpellier, France. g-cambonie@chu-montpellier.fr.ORCID http://orcid.org/0000-0002-1360-7915

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates whether implementation of a less-invasive surfactant administration (LISA) protocol in a level IIIb academic neonatal intensive care unit had an impact on the rate of infants treated with surfactant. This observational cohort study enrolled spontaneously breathing very premature infants, born < 33 weeks' gestational age (GA), with worsening respiratory distress syndrome despite support with continuous positive airway pressure and in need of surfactant replacement therapy. Data were collected over two 3-year periods, preceding (P1, 2013-2015) and following (P2, 2019-2021) implementation of a LISA protocol. Nine hundred and six neonates were studied, 412 (45%) born in P1 and 494 (55%) in P2, with comparable GA, birthweight, and severity score (CRIB-II). Administration technique was mainly conventional at P1 (85%) and LISA at P2 (75%). Surfactant treatment rate decreased from 54% (224/412) at P1 to 47% (233/494) at P2 (p = 0.04), notably in infants born at 28-32 weeks' GA (41 to 33%, OR [95% CI] 0.72 [0.53-0.99]). Among 23-32 weeks' GA infants, need for invasive mechanical ventilation decreased from 56% (231/412) at P1 to 23% (113/494) at P2 (OR 0.23 [0.17-0.31], p < 0.001). Mortality and survival without severe morbidity were comparable. Conclusion: Implementation of a LISA protocol in our level IIIb NICU was associated with less surfactant use and lower exposure to invasive mechanical ventilation.

Indexed as

Pulmonary SurfactantsRespiratory Distress Syndrome, NewbornContinuous Positive Airway PressureFemaleGestational AgeHumansInfant, Extremely PrematureInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalMaleTreatment OutcomePulmonary SurfactantsBronchopulmonary dysplasiaMechanical ventilationNoninvasive ventilationPremature infantPulmonary surfactantsRespiratory distress syndrome

Identifiers

PMID40828341

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.