ArticleAnnals of medicine2025
Multi-omics analysis and validation of autophagy-related diagnostic biomarker in osteoarthritis.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review).International journal of molecular medicine · 2026Review
- Secoisolariciresinol diglucoside alleviates inflammatory injury in osteoarthritis chondrocytes through ERBB2-associated JAK2/STAT3 signaling: network pharmacology and experimental validation.Frontiers in immunology · 2026Article
- The dual role of autophagy in cartilage degradation: from mechanisms to targeted therapeutics.Frontiers in cell and developmental biology · 2026Review
- Multimodal analysis reveals potential association of CDH13 with endothelial cells and its overexpression in hepatocellular carcinoma.European journal of medical research · 2025Article
- Screening and identification of differentially expressed miRNA and mRNA for intervertebral disc degeneration on bioinformatics.European journal of medical research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutophagy plays an essential regulatory role in the development of osteoarthritis (OA), its specific regulatory mechanism remains unclear. This work aims to study the critical genes related to autophagy in OA and explore their potential value.
methodsDatasets were downloaded from the publicly available GEO database, and differentially expressed autophagy-related genes (ARGs) were obtained. LASSO regression analysis, SVM-RFE algorithm, and RF algorithm were used to screen signature genes. The diagnostic accuracy of autophagy-related signature genes (ARSGs) in OA was determined through receiver operating characteristic (ROC) univariate analysis. The accuracy of the results was validated with an external dataset. Signature genes were analyzed for immune-related functions. Single-gene cluster enrichment analysis (GSEA) and single-gene set variation analysis (GSVA) were employed to demonstrate the potential biological functions of signature genes. Competing endogenous RNA networks, including miRNAs and lncRNAs, and drug regulatory networks were constructed to search for potential therapeutic targets. The expression levels of key ARSGs were verified through qRT-PCR, Western blot, immunohistochemistry (IHC) analyses, and animal model construction.
resultsA total of 12 up-regulated genes and 37 down-regulated genes were identified and found to be associated with autophagy regulation and inflammatory pathways. Screening identified three candidate genes, namely,
conclusions
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.