Evidence map›Paper›PMID 40828224›Full record

ReviewAnnals of biomedical engineering2025

An Overview of Approaches and Evaluation Methods for Tissue-Engineered Articular Cartilage Constructs in Animal Models.

S H Aswathy, U Narendrakumar, I Manjubala

Abstract readReview
PubMed Publisher
In one paragraph

Review in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

S H AswathyDepartment of Biosciences, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 632014, India.
U NarendrakumarDepartment of Manufacturing Engineering, School of Mechanical Engineering, Vellore Institute of Technology, Vellore, 632014, India.
I ManjubalaDepartment of Biosciences, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, 632014, India. i.manjubala@vit.ac.in.

Funding

DST-SERB EMR/2017/003504
6 · The paper itself

Abstract

One of the predominant clinical challenges faced by orthopedic practitioners and researchers is the regeneration of articular cartilage. Articular cartilage lesions and/or defects, as well as degeneration, are the primary causes of knee cartilage impairment. Tissue-engineered articular cartilage constructs are being developed to restore articular cartilage. Recent developments in the design of biomaterials have enabled the creation of many promising biomaterials for articular cartilage restoration. The purpose of this review is to provide researchers in the field of tissue engineering with a general overview of the approaches being used to examine articular cartilage and the evaluation methods being used to assess tissue-engineered constructs in animal models. Most tissue-engineered cartilage constructs tested in animal models are evaluated at least macroscopically and histologically. Furthermore, ICRS gross morphology scoring, immunohistochemistry, biochemical assays, biomechanical testing, gene expression analysis, and imaging techniques have been used to evaluate the regeneration potential of tissue-engineered constructs. This review also presents a comprehensive summary of the animal models used in the evaluation of tissue-engineered constructs for cartilage regeneration.

Indexed as

Cartilage, ArticularTissue EngineeringAnimalsHumansModels, AnimalRegenerationTissue ScaffoldsArticular cartilage defectsEvaluation methodsPreclinical studiesTissue-engineered constructs

Identifiers

PMID40828224

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.