ArticleOral health & preventive dentistry2025
Analysis of Oral Microbiota in Herpetiform Aphthous Ulcers Patients.
Article in Oral health & preventive dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Oral mucosal microbiome alterations in recurrent aphthous stomatitis: a systematic review of 16 S rRNA gene sequencing studies.Molecular biology reports · 2026Pooled it
- How Nutrient Deficiencies Impact the Oral Mucosa and How to Manage Them: A Narrative Review.Nutrients · 2026Review
- Pain severity trajectory and influencing factors in children with recurrent aphthous stomatitis: a latent variable growth mixture model.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo examine the microbiota in the oral mucosa and saliva of patients with herpetiform aphthous ulcers (HAU) and compare it with healthy individuals. MATERIALS AND
methods16S rRNA sequencing was employed to analyze the oral mucosal bacterial communities of healthy individuals (healthy controls) and HAU patients (ulcerated sites, healthy sites, and healed ulcer sites).
resultsSpecies richness in patients with HAU was statistically significantly lower than in healthy individuals. At the phylum level, the abundance of Firmicutes in the healthy sites of HAU patients was lower, while that of Proteobacteria was higher compared to healthy controls. In the ulcerated sites, the abundance of Firmicutes diminished, and the abundance of Proteobacteria increased relative to the healthy sites. In the healed ulcer sites, the abundance of these two phyla had partially recovered but had not yet reached the level of healthy sites in the ulcer phase. At the genus level, the abundance of Streptococcus in the healthy sites of HAU patients was lower than that in healthy controls, whereas Haemophilus_D was higher. In the ulcerated sites, the abundance of Streptococcus decreased, while the abundances of Neisseria and Haemophilus_D increased compared to the healthy sites. In the healed ulcer sites, the abundance of these three bacterial genera recovered to levels close to those in healthy sites during the ulcer phase. LEfSe analysis indicated that o_Enterobacterales_A, f_Pasteurellaceae, f_Erysipelotrichaceae, g_Bulleidia, f_Peptoniphilaceae, and g_Parvimonas were identified as biomarkers in the ulcerated sites.
conclusionThese findings highlight the distinct microbial signatures associated with HAU and suggest that microbial community changes may play a role in disease progression and healing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.