Evidence map›Paper›PMID 40828030›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Aspartic acid residues in BBE-like enzymes from

Nianxin Guo, Jun Gu, Qingyang Zhou, Fang Liu, Haoran Dong, Qi Ding, Qixuan Wang, Dongshan Wu, Jun Yang, Junping Fan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Genome-Wide Identification and Functional Verification of CoreInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nianxin Guo *Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.ORCID 0009-0004-7973-7490
Jun Gu *School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Qingyang ZhouDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095-1569.
Fang LiuDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095-1569.
Haoran DongBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Qi DingBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Qixuan WangPeking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.
Dongshan WuBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Jun YangBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.ORCID 0000-0002-2785-6971
Junping FanBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.ORCID 0000-0002-2615-8098
Lei GaoBeijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.ORCID 0000-0003-3033-5285
Kendall N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095-1569.ORCID 0000-0002-8387-5261
Xiaoguang LeiPeking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0002-0380-8035

Funding

CAS | ICCAS | Beijing National Laboratory for Molecular Sciences (BNLMS) BNLMS-CXX-202106MOST | National Key Research and Development Program of China (NKPs) 2022YFC3401500| National Natural Science Foundation of China 22193073| National Natural Science Foundation of China 92253305National Natural Science Foundation of China 22322701United States NSF CHE-2153972
6 · The paper itself

Abstract

Berberine bridge enzyme (BBE)-like enzymes catalyze various oxidative cyclization and dehydrogenation reactions in natural product biosynthesis, but the molecular mechanism underlying the selectivity remains unknown. Here, we elucidated the catalytic mechanism of BBE-like oxidases from

Indexed as

Aspartic AcidMorusOxidoreductasesPlant ProteinsCrystallography, X-RayCyclizationMolecular Dynamics SimulationOxidation-ReductionAspartic AcidOxidoreductasesPlant ProteinsBBE-like enzymebiocatalysiscatalytic mechanismdehydrogenationoxidative cyclization

Identifiers

PMID40828030
PMCPMC12403149

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.