ArticleProceedings of the National Academy of Sciences of the United States of America2025
Life's homochirality: Across a prebiotic network.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A highly limited amino acid library from asteroid Bennu yields wide-ranging protein folds.Nature communications · 2026Article
- 2-Hydroxyglutarate in onco-pathway: a metabolic driver of proto-oncogene activation.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For centuries, scientists have been puzzled by the mystery of life's biomolecular homochirality-the single-handedness of biological compounds. Sugars and nucleic acids are right-handed, while amino acids are left-handed in biological systems. Likewise, certain metabolites are homochiral, though their handedness varies. However, efforts to address the homochirality problem have often focused on a single compound, a single molecular class, or invoke an extraterrestrial origin. Here, we emphasize the importance of achieving homochirality across an entire prebiotic chemical network and explore a terrestrial pathway for its emergence. This pathway is supported by recent experimental results from several independent studies, as well as analyses of pristine asteroid materials. Our analysis identifies the genome as a key site for achieving network-scale homochirality on early Earth and addresses the opposite handedness of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.