Evidence map›Paper›PMID 40828020›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability.

Haeun Kim, Ya-Min Tian, Peter J Ratcliffe, Thomas P Keeley

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. A C-degron regulates Chk1 kinase by allowing stability of inactive Chk1 and by making it short- lived upon activation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Power and poison: The intersections of HThe Journal of biological chemistry · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Haeun Kim *Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.ORCID 0009-0006-5852-903X
Ya-Min Tian *Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.
Peter J RatcliffeTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.ORCID 0000-0002-2853-806X
Thomas P KeeleyTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, United Kingdom.ORCID 0000-0002-0334-7144

Funding

British Heart Foundation (BHF) FS/IBSRF/24/25194Ludwig Institute for Cancer Research (LICR) Core FundingWellcome Trust FC001501Wellcome Trust (WT) 106241/Z/14/ZWellcome Trust (WT) 301530/Z/23/Z
6 · The paper itself

Abstract

Selected proteins containing an N-terminal cysteine (Nt-Cys) are subjected to rapid, O

Indexed as

CysteineNitric OxideOxygenProteolysisAnimalsDegronsHumansCysteineNitric OxideOxygenhypoxiaN-degronnitric oxideoxygenproteolysis

Identifiers

PMID40828020
PMCPMC12403002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.