Evidence map›Paper›PMID 40828018›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Loss of sialic acid side-chain

Yang Ji, Shubham Parashar, Yukiko Miyamoto, Saurabh Srivastava, Amanda L Lewis, Nissi Varki, Ajit Varki, Lars Eckmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yang Ji *Department of Medicine, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0002-7409-7824
Shubham Parashar *Department of Medicine, University of California San Diego, La Jolla, CA 92093.
Yukiko MiyamotoDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0001-5650-699X
Saurabh SrivastavaDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.
Amanda L LewisDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0001-6195-3030
Nissi VarkiDepartment of Pathology, University of California-San Diego, La Jolla, CA 92093.
Ajit VarkiDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0002-2206-975X
Lars EckmannDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0002-7987-8742

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK120515HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM032373NIDDK NIH HHS P30 DK120515
6 · The paper itself

Abstract

Sialic acids (Sias) are a diverse family of nine-carbon backbone monosaccharides occupying terminal positions on cell surface and secreted glycans and are abundant at mucosal surfaces. Sias can be modified with

Indexed as

AcetyltransferasesColitisN-Acetylneuraminic AcidSialic AcidsAcetylationAnimalsColonFemaleGastrointestinal MicrobiomeHumansIntestinal MucosaMaleMiceMice, Inbred C57BLMice, KnockoutAcetyltransferasesN-Acetylneuraminic AcidSialic Acidsglycobiologyintestinal inflammationmicrobiomesialic acids

Identifiers

PMID40828018
PMCPMC12403103

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.