Evidence map›Paper›PMID 40827970›Full record

ArticleThe Review of scientific instruments2025

Compact 1 GHz electron paramagnetic resonance spectrometer and imager.

Tanden A Hovey, Lukas B Woodcock, Georgina Amassah, Autumn Canny, Francisco J Roberto, George A Rinard, Sandra S Eaton, Gareth R Eaton

Abstract read
In one paragraph

Article in The Review of scientific instruments, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tanden A HoveyDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80210, USA.ORCID 0000-0001-8676-1270
Lukas B WoodcockDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80210, USA.ORCID 0000-0001-6906-0296
Georgina AmassahDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80210, USA.ORCID 0009-0006-4662-4689
Autumn CannyDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80210, USA.ORCID 0009-0003-8000-8474
Francisco J RobertoDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80210, USA.ORCID 0009-0009-9898-299X
George A RinardRitchie School of Engineering and Computer Science, University of Denver, Denver, Colorado 80210, USA.ORCID 0009-0005-2781-2249
Sandra S EatonDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80210, USA.ORCID 0000-0002-2731-7986
Gareth R EatonDepartment of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80210, USA.ORCID 0000-0001-7429-8469

Funding

Preclinical Electron Paramagnetic Resonance Tumor ImagerR01CA262159 · NCI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI EATON, GARETH R · 2021 to 2025
$2.6M
NCI NIH HHS R01 CA262159
6 · The paper itself

Abstract

A 1 GHz preclinical electron paramagnetic resonance spectrometer and imager has been developed to study low concentrations of radicals using rapid-scan detection. The design focuses on minimizing the losses between the resonator and the first-stage low-noise amplifier. The adjustable-frequency source with the lowest available noise was selected and the output was amplified to provide sufficient power for experiments with relatively rapidly relaxing nitroxide radicals. For resonators with similar geometries and efficiencies, improved signal to noise was demonstrated relative to our previous instrument that operates at 700 MHz, consistent with predictions for frequency dependence. System performance was demonstrated for solutions of nitroxide radicals in resonators that contain 8 mm or 25 mm diameter cylindrical tubes. For 15N-d16 tempone in aqueous solution and a signal averaging time of 3.8 s, a signal-to-noise of 3 required 2 × 1014 spins in the 8 mm resonator or 4.5 × 1015 spins in the 25 mm resonator. 3D spatial imaging was demonstrated with a phantom consisting of three tubes containing solutions of a nitroxide radical.

Identifiers

PMID40827970
PMCPMC12901536

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.