Evidence map›Paper›PMID 40827946›Full record

ArticleJournal of chemical information and modeling2025

Discovery and Characterization of Uracil Derivatives Targeting the Set-and-Ring Domain of UHRF1.

Ifigeneia Akrani, Danai Driva, Efstratios Tsakalidis, Nandini Mozumdar, Danai Mavridi, Anthi Panara, Kalypso Epiphaniou, Maria Chalkiadaki, Andreanna Frances Wright, Maria Halabalaki and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of chemical information and modeling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ifigeneia AkraniDivision of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.
Danai DrivaDivision of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.
Efstratios TsakalidisDivision of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.ORCID 0009-0004-3197-1624
Nandini MozumdarLudwig Institute for Cancer Research, Nuffield Department of Medicine, Old Road Campus Research Building, OX3 7DQ, Oxford, United Kingdom.
Danai MavridiDivision of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.ORCID 0009-0004-7379-9527
Anthi PanaraLaboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.
Kalypso EpiphaniouDivision of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.
Maria ChalkiadakiDivision of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.
Andreanna Frances WrightMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, EH4 2XU, Edinburgh, United Kingdom.
Maria HalabalakiDivision of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.ORCID 0000-0001-5620-0165
Angeliki TsokaDepartment of Biology, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.
Grigoris ZoidisDivision of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.ORCID 0000-0002-9442-5186
Constantinos VorgiasDepartment of Biology, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.
Duncan SproulMedical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, EH4 2XU, Edinburgh, United Kingdom.
Evangelos GikasLaboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.ORCID 0000-0002-0107-9991
Skirmantas KriaucionisLudwig Institute for Cancer Research, Nuffield Department of Medicine, Old Road Campus Research Building, OX3 7DQ, Oxford, United Kingdom.
Emmanuel MikrosDivision of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.ORCID 0000-0002-5984-5169
Vassilios MyrianthopoulosDivision of Pharmaceutical Chemistry, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou 15771, Athens, Greece.ORCID 0000-0001-8359-9634

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Set and Ring domain of the UHRF1 oncogene is responsible for its interaction with hemimethylated DNA and faithful propagation of epigenetic signaling over cellular replication. Inhibiting this recognition can have serious implications for UHRF1 functionality and may possibly enable therapeutic interventions. Based on a previous finding indicating a promising

Indexed as

CCAAT-Enhancer-Binding ProteinsDrug DiscoveryUracilDNA MethylationHumansMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingProtein DomainsThermodynamicsUbiquitin-Protein LigasesCCAAT-Enhancer-Binding ProteinsUbiquitin-Protein LigasesUHRF1 protein, humanUracil

Identifiers

PMID40827946
PMCPMC12421671

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.