Evidence map›Paper›PMID 40827906›Full record

ArticleJournal of clinical microbiology2025

Evaluation of fully automated chemiluminescent enzyme immunoassays for hepatitis B core-related antigen components, phosphorylated and non-phosphorylated hepatitis B core antigens: clinical significance and dynamics during hepatitis B e antigen seroconversion.

Takanori Suzuki, Chiharu Ohue, Osamu Arai, Yuka Inose, Katsuya Nagaoka, Shintaro Ogawa, Takako Inoue, Kentaro Matsuura, Katsumi Aoyagi, Shintaro Yagi and 1 more

Erratum issuedAbstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Takanori Suzuki *Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Chiharu Ohue *Advanced Life Science Institute Inc.Tokyo, Japan.
Osamu AraiAdvanced Life Science Institute Inc.Tokyo, Japan.
Yuka InoseAdvanced Life Science Institute Inc.Tokyo, Japan.
Katsuya NagaokaDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID 0000-0002-7152-6101
Shintaro OgawaDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID 0000-0002-5203-9324
Takako InoueDepartment of Clinical Laboratory Medicine, Nagoya City University Hospital, Nagoya, Japan.ORCID 0000-0001-8801-5888
Kentaro MatsuuraDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.ORCID 0009-0005-0163-3971
Katsumi AoyagiAdvanced Life Science Institute Inc.Tokyo, Japan.
Shintaro YagiAdvanced Life Science Institute Inc.Tokyo, Japan.ORCID 0000-0002-2671-4058
Yasuhito TanakaDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID 0000-0002-2473-6966

Funding

Japan Agency for Medical Research and Development JP24fk0310518, 25fk0310543
6 · The paper itself

Abstract

To assess the performance and clinical relevance of three assays-hepatitis B core-related antigen (HBcrAg), hepatitis B core antigen (HBcAg), and phosphorylated HBcAg (pHBcAg)-in quantifying HBcrAg, a critical biomarker of hepatitis B virus (HBV) infection, fully automated chemiluminescent enzyme immunoassays (CLEIA) for two HBcAg variants were developed. Cutoff values for HBcAg and pHBcAg assays were established at 2.50 and 2.10 LogU/mL, respectively. The strong correlations among components (

Indexed as

Hepatitis BHepatitis B, ChronicHepatitis B Core AntigensHepatitis B e AntigensLuminescent MeasurementsAdultAutomation, LaboratoryBiomarkersClinical RelevanceFemaleHepatitis B virusHumansImmunoenzyme TechniquesMaleMiddle AgedPhosphorylationBiomarkersHepatitis B Core AntigensHepatitis B e AntigensCLEIAclinical utilityHBcAgHBcrAgHBV particlesphosphorylated HBcAg

Identifiers

PMID40827906
PMCPMC12421862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.