Evidence map›Paper›PMID 40827900›Full record

ArticleMicrobiology spectrum2025

An international multi-site study to evaluate the analytical and clinical performance of the quantitative high-throughput Alinity m CMV assay.

Julie W Hirschhorn, Mark M Sasaki, Yan Chin Tai, April Kegl, Tanjina Akter, Tanisha Dickerson, Momka Narlieva, Nhi Nhan, Tianxi Liu, Eriel Thornton and 10 more

Abstract readMulticenter StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Julie W HirschhornDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.ORCID 0000-0001-9717-408X
Mark M SasakiMolecular Diagnostics at Abbott, Des Plaines, Illinois, USA.
Yan Chin TaiAbbott Laboratories (Singapore) Pte. Ltd., Singapore, Singapore.
April KeglDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Tanjina AkterDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Tanisha DickersonDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Momka NarlievaDepartment of Pathology, Montefiore Medical Center, Bronx, New York, USA.
Nhi NhanDepartment of Pathology, Montefiore Medical Center, Bronx, New York, USA.ORCID 0009-0008-1262-1484
Tianxi LiuDepartment of Pathology, Montefiore Medical Center, Bronx, New York, USA.
Eriel ThorntonMolecular Diagnostics at Abbott, Des Plaines, Illinois, USA.
Patricia JimTriCore Reference Laboratories, Albuquerque, New Mexico, USA.
Ya-Jhu LinDepartment of Laboratory Medicine, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Li-An WuDepartment of Laboratory Medicine, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Tzu-Hsuan HsiehDepartment of Laboratory Medicine, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Po-Wei HuangDepartment of Laboratory Medicine, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Jen-Fu Hsu *Department of Neonatology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Stephen YoungTriCore Reference Laboratories, Albuquerque, New Mexico, USA.
Danijela LucicMolecular Diagnostics at Abbott, Des Plaines, Illinois, USA.ORCID 0000-0002-7276-489X
D Yitzchak GoldsteinDepartment of Pathology, Montefiore Medical Center, Bronx, New York, USA.ORCID 0000-0001-6367-8335
Chung-Guei Huang *Department of Laboratory Medicine, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytomegalovirus (CMV) has a high prevalence in the general population and lifelong latency once an individual is infected. Primary infection or reactivation of CMV in immunocompromised individuals can lead to serious illness, organ failure, and death. Precise and accurate quantification of CMV is a valuable tool to support clinical decision-making and prevent adverse outcomes in transplant recipients. This international multicenter study evaluated the analytical performance of the Alinity m CMV assay using a commercially available panel (2.30 to 6.60 Log IU/mL) and clinical performance compared to the Abbott RealTi

Indexed as

CytomegalovirusCytomegalovirus InfectionsHigh-Throughput Screening AssaysMolecular Diagnostic TechniquesHumansImmunocompromised HostSensitivity and SpecificityViral LoadCMVhigh-throughput diagnosticnucleic acid amplification testtransplantviral load monitoring

Identifiers

PMID40827900
PMCPMC12502681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.