Evidence map›Paper›PMID 40827842›Full record

Trial reportThe American journal of hospice & palliative care2026

The Effect of the Care Ecosystem Collaborative Care Model on End-of-Life Outcomes for People With Dementia and Their Caregivers.

Lauren J Hunt, Krista L Harrison, Rachel Kiekhofer, Jennifer Merrilees, Alissa B Sideman, Sarah Dulaney, I Elaine Allen, Kirby Lee, Winston Chiong, Sarah M Hooper and 4 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of hospice & palliative care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lauren J HuntPhilip R. Lee Institute for Health Policy Studies, University of California, San Francisco, CA, USA.ORCID 0000-0002-2731-2173
Krista L HarrisonPhilip R. Lee Institute for Health Policy Studies, University of California, San Francisco, CA, USA.ORCID 0000-0001-5373-3011
Rachel KiekhoferDepartment of Neurology, University of California, San Francisco, CA, USA.
Jennifer MerrileesDepartment of Neurology, University of California, San Francisco, CA, USA.
Alissa B SidemanPhilip R. Lee Institute for Health Policy Studies, University of California, San Francisco, CA, USA.
Sarah DulaneyDepartment of Neurology, University of California, San Francisco, CA, USA.
I Elaine AllenDepartment of Epidemiology & Biostatistics, University of California, San Francisco, CA, USA.
Kirby LeeDepartment of Clinical Pharmacy, University of California, San Francisco, CA, USA.
Winston ChiongDepartment of Neurology, University of California, San Francisco, CA, USA.
Sarah M HooperUCSF/UC Law SF Consortium, UC Law, San Francisco, CA, USA.
Stephen J BonaseraBay State Health, Division of Geriatrics, Palliative, and Post-Acute Care, Springfield, MA, USA.
Tamara L BraleyCollege of Nursing-Omaha DivisionUniversity of Nebraska Center, Omaha, NE, USA.
Bruce L MillerThe Global Brain Health Institute, University of California, San Francisco, CA, USA.
Katherine L PossinThe Global Brain Health Institute, University of California, San Francisco, CA, USA.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Louise C. Walter · 2013 to 2026
$19.9M
The Care Ecosystem Response to COVID-19: Accelerating Research on Dementia Care that Meets the Needs of Caregivers and Persons with Dementia during COVID-19R01AG074710 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL · 2022 to 2024
$9.1M
Augmenting Nurse Support and EHR Integration for the Pragmatic Trial of the UCSF-BHAU01NS128913 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine Laurel Possin · 2022 to 2026
$8.2M
US-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1M
The Care Ecosystem: Navigating patients and caregivers through stages of dementia careR01AG056715 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL · 2017 to 2021
$6.0M
The UCSF Brain Health Assessment for the Detection of Cognitive Impairment Among Diverse Populations in Primary CareUH3NS105557 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL · 2019 to 2021
$4.9M
Hospice Use in Older Adults with Alzheimer's Disease and Related Dementias: Patterns, Policies, and Caregiver ExperiencesK76AG074924 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUNT, LAUREN · 2021 to 2025
$1.1M
Palliative Care for People Living at Home with Advancing Dementia and Their CaregiversK01AG059831 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HARRISON, KRISTA LYN · 2019 to 2023
$720k
Mapping the Dynamics of Caregiver Burden in Alzheimer's DiseaseK01AG059840 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SIDEMAN, ALISSA BERNSTEIN · 2020 to 2024
$652k
NIA NIH HHS K01 AG059831NIA NIH HHS K01 AG059840NIA NIH HHS K76 AG074924NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG044281NIA NIH HHS R01 AG056715NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG074710NINDS NIH HHS U01 NS128913NINDS NIH HHS UH3 NS105557
6 · The paper itself

Abstract

ContextCollaborative care models that feature care navigation have been found to have a range of benefit for people with dementia (PWD) and their caregivers, but their effect on end-of-life (EOL) outcomes has not been robustly evaluated.ObjectivesOur primary objective was to evaluate the effect of the Care Ecosystem-a telephone-based collaborative care model for dementia with care navigation-on EOL outcomes for PWD and their caregivers. Our secondary objective was to use qualitative feedback from participants to identify supports and services that would be helpful at end of life, including how the Care Ecosystem and other EOL supports could be improved.MethodsMixed-methods analysis of the Care Ecosystem trial conducted 2015-2022. Pre-mortem and post-mortem surveys included close-ended validated measures (eg, satisfaction with end-of-life care, caregiver self-efficacy) and open-ended questions about EOL care.ResultsThere were 138/124 dyads randomized to Care Ecosystem and 76/65 randomized to Usual Care in the pre-mortem/post-mortem cohorts. Compared to Usual Care, Care Ecosystem caregivers had higher ratings of caregiver self-efficacy prior to PWD death (Adjusted unstandardized Beta 0.94 95% CI 0.23, 1.65,

Indexed as

CaregiversDementiaTerminal CareAgedAged, 80 and overCooperative BehaviorFemaleHumansMaleMiddle AgedPatient NavigationSelf EfficacyTelephonecaregivers end of lifecare navigationdementiasupports collaborative care models

Identifiers

PMID40827842
PMCPMC12974891

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.