ArticleInternal medicine journal2025
Neurological manifestations of chronic graft versus host disease.
Article in Internal medicine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Patient-reported outcomes in chronic GVHD: instruments, clinical utility, and survivorship integration.Journal of patient-reported outcomes · 2026Review
- Extracorporeal photopheresis therapy for graft-versus-host disease with atypical neurological manifestations: a case report.Annals of hematology · 2026Article
- Neurological graft-versus-host disease with MOG antibody positivity after allogeneic stem cell transplantation: a case report.Frontiers in immunology · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAllogeneic haemopoietic stem cell transplant (allo-HSCT) is an established therapy for many malignant and non-malignant conditions, with an increasing number of uses and indications in recent decades. Complications including graft versus host disease (GvHD) carry significant morbidity and mortality. Chronic GvHD can affect multiple organs, including skin, gastrointestinal, respiratory and eyes. Neurological involvement is less common and can be a diagnostic and therapeutic challenge for patients and clinicians.
methodsA retrospective analysis was conducted of patients who underwent allo-HSCT for a haematological malignancy with an established diagnosis of chronic GvHD at a major Australian institution.
resultsOut of 455 allo-HSCT cases, 228 (50%) had chronic GvHD, seven (3.1%) of which were identified to have neurological complications. Four cases, each consisting of myasthenia gravis, Bickerstaff brainstem encephalitis, acute disseminated encephalomyelitis and inflammatory meningitis, were selected to illustrate peripheral and central neurological manifestations of chronic GvHD. Presentations, management and outcomes were discussed and contrasted to similar cases available in the literature.
conclusionChronic GvHD infrequently presents with neurological manifestations. Understanding the similarities and differences of these and their idiopathic counterparts allows an enhanced understanding of their pathophysiology within the context of GvHD, as well as some significant differences to conventional management of these neurological conditions.
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