Myelination of the retinal nerve fibre layer: A case report.

Gioia Riboni-Verri, Riddhima Gautam, Benson Chen, Nick G Cunniffe

Abstract readCase Reports

In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Gioia Riboni-VerriDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Cambridge Clinical Vision Laboratory, University of Cambridge, Cambridge, UK.ORCID 0000-0001-7688-7638

Riddhima GautamCambridge Clinical Vision Laboratory, University of Cambridge, Cambridge, UK.

Benson ChenDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Cambridge Clinical Vision Laboratory, University of Cambridge, Cambridge, UK; Department of Medicine, University of Auckland, Auckland, New Zealand.

Nick G CunniffeDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK; Cambridge Clinical Vision Laboratory, University of Cambridge, Cambridge, UK.ORCID 0000-0002-7562-2838

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAberrant myelination of the retinal nerve fibre layer (RNFL) can follow lamina cribrosa damage. Such cases may provide insight into how increased myelin affects the visual evoked potential (VEP), a key outcome in remyelination trials.

objectiveWe present the case of a myelinated RNFL in a patient with relapsing-remitting multiple sclerosis (RRMS) with accompanying electrophysiology.

methodsVisual assessments used a VisionSearch Plus, Heidelberg Spectralis optical coherence tomography, and Topcon fundus camera.

resultsFull-field visual evoked potential (FF-VEP) peak time latency was abnormally short, 90 ms.

conclusionThis is the first known case report of a myelinated RNFL with electrophysiology, which supports the assertion that reductions in VEP latency correlate with myelination.

Indexed as

Evoked Potentials, VisualMultiple Sclerosis, Relapsing-RemittingMyelin SheathNerve Fibers, MyelinatedRetinaAdultFemaleHumansTomography, Optical CoherenceMultiple sclerosismyelinneuroophthalmologyremyelinationvisual evoked potentials

Identifiers

PMID40827818

DOI10.1177/13524585251365793

PMCPMC12953666

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