ArticleMicrobiologyOpen2025
Assessment of Hypervirulent Klebsiella pneumoniae Isolates Using Multilocus Sequence Typing in West of Iran.
Article in MicrobiologyOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Multidrug-resistantNew microbes and new infections · 2026Article
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6 authors.
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Abstract
backgroundHypervirulent Klebsiella pneumonia (hvKP) has been considered due to severe infections such as pyogenic liver abscess, pneumonia, meningitis, endophthalmitis and necrotizing fasciitis. Due to the importance of the subject, hvKP isolates were investigated in the current study.
methodsA total of 52 non-repetitive Klebsiella pneumonia (K. pneumonia) isolates were collected from clinical specimens (pleural fluid, blood, urine and trachal aspiration) of hospitalized patients in three well-known hospitals in Ilam, west of Iran. Phenotypic tests, including the string test and potassium tellurite resistance, and molecular methods such as polymerase chain reaction (PCR) for iucA, iroB, iutA, and rmpA genes were used for hvKP diagnosis. In addition, multilocus sequence typing (MLST) was used to clarify the genetic relationships between isolates.
resultsThe mrkD, iroB, iucA, iutA, and rmpA genes were present in 6 (11.53%), 4 (7.7%), 12 (23.1%), 5 (9.6%), and 8 (15.4%) of the K. pneumoniae isolates, respectively. Eight isolates from different sources were identified with new sequence types (STs). These newly identified STs include ST-7466, ST-7467, ST-7468, ST-7469, ST-7470, ST-7471, ST-7472 and ST-7473.
conclusionsWe reported the eight new STs based on the MLST method for the phylogenetics of hvKP isolates. Our data indicated that no correlation between the phylogenetics of hvKP isolates. So, more extensive studies are needed to better understand the epidemiology of hvKP.
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