SynthesisPediatric pulmonology2025
Risk Factors for Life-Threatening Asthma Attacks and Asthma-Related Mortality in Children-A Systematic Review.
Synthesis in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Asthma and Multimorbidity Amongst Ethnic Minority Groups in High Income Countries.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundAwareness of factors associated with life-threatening asthma attacks and asthma mortality is essential for risk prediction in asthma care. There is limited evidence to inform risk factors in children and young people (CYP). The aim of this systematic review is to synthesize existing data to report risk factors for life-threatening asthma attacks and asthma deaths in CYP.
methodsThis review followed PRISMA-reporting-guidelines and was registered on PROSPERO (CRD42023494203). We included observational studies of CYP aged 0-18 years with asthma, published in English, from 2000 to the present, exploring variables influencing asthma mortality and life-threatening attacks (defined as intensive care [ICU] admissions). CINAHL, MEDLINE, Central Cochrane Library, and Scopus databases were searched. Reference lists of eligible studies were screened. The MEDLINE search strategy was adapted across the databases. Results were synthesized narratively.
resultsSix studies met our inclusion criteria (five retrospective cohort, one case-control study). All were conducted in high-income countries. In descending order of strength of association, factors found to be associated with ICU admissions were: high salbutamol use, previous hospitalization, low socioeconomic status, allergies, Black ethnicity, prescription of asthma medications, history of pneumonia, rural location, adolescence, paternal asthma, and co-existing comorbidity. For the outcome of mortality, one study reported a sevenfold risk of asthma death in children of Black ethnicity compared with White. The included studies had low quality of evidence by the GRADE assessment.
conclusionThe small number and high heterogeneity between available studies, identifies a need for robust epidemiological studies and better risk prediction for near-fatal and fatal attacks in CYP-asthma.
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