Evidence map›Paper›PMID 40827662›Full record

ArticleGut microbes2025

Estrogen-related receptor alpha mitigates radiation-induced bowel injury through gut enrichment of

Seul Gi Shin, June-Young Lee, Jee-Won Choi, Ji-Ho Yoo, In-Chul Jeong, Do-Yeon Kim, Hyun Sik Kim, Seungwha Paik, Gyu-Yong Song, Kyung-Hee Kim and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Seul Gi ShinDepartment of Microbiology, Chungnam National University College of Medicine, Daejeon, South Korea.ORCID 0000-0001-7657-6098
June-Young LeeDepartment of Biology, Kyung Hee University, Seoul, South Korea.ORCID 0000-0002-6793-6108
Jee-Won ChoiDepartment of Biology, Kyung Hee University, Seoul, South Korea.ORCID 0000-0003-3767-2911
Ji-Ho YooDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul, South Korea.ORCID 0000-0001-5507-3707
In-Chul JeongDepartment of Biology, Kyung Hee University, Seoul, South Korea.ORCID 0009-0000-7867-5794
Do-Yeon KimDepartment of Biology, Kyung Hee University, Seoul, South Korea.ORCID 0000-0002-5958-9679
Hyun Sik KimDepartment of Biology, Kyung Hee University, Seoul, South Korea.ORCID 0000-0002-2786-4701
Seungwha PaikDepartment of Microbiology, Chungnam National University College of Medicine, Daejeon, South Korea.ORCID 0000-0002-5015-1494
Gyu-Yong SongCollege of Pharmacy, Chungnam National University, Daejeon, South Korea.ORCID 0000-0001-6058-5790
Kyung-Hee KimDepartment of Pathology, Chungnam National University School of Medicine, Daejeon, South Korea.ORCID 0000-0003-0214-0296
Jin-Man KimDepartment of Pathology, Chungnam National University School of Medicine, Daejeon, South Korea.ORCID 0000-0003-0905-9730
Jin-Woo BaeDepartment of Biology, Kyung Hee University, Seoul, South Korea.ORCID 0000-0001-6433-5270
Eun-Kyeong JoDepartment of Microbiology, Chungnam National University College of Medicine, Daejeon, South Korea.ORCID 0000-0001-7191-0587
Sup KimDepartment of Radiation Oncology, Chungnam National University School of Medicine, Daejeon, South Korea.ORCID 0000-0003-1936-7737

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiation-induced gastrointestinal (GI) toxicity can be a major cause of morbidity in patients undergoing abdominal radiotherapy. There is an unmet need for treatments to ameliorate GI toxicity. Estrogen-related receptor alpha (ESRRA), a protein involved in the regulation of inflammation and autophagy, is widely expressed across human tissues. Our recent findings on ESRRA's significant contribution to intestinal homeostasis and inflammation control in inflammatory bowel disease inspired us to investigate its potential role in radiation-induced gastrointestinal injury.

Indexed as

BacteroidesGastrointestinal MicrobiomeRadiation InjuriesReceptors, EstrogenAnimalsERRalpha Estrogen-Related ReceptorFemaleHumansIntestinesMaleMiceMice, Inbred C57BLMice, KnockoutERRalpha Estrogen-Related ReceptorReceptors, EstrogenBacteroides vulgatusESRRAintestinal homeostasisradiation-induced gastrointestinal toxicity

Identifiers

PMID40827662
PMCPMC12366819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.