ArticleThe British journal of surgery2025
Comparison of outcomes after living and deceased donor kidney transplantation: UK national cohort study.
Article in The British journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Predictors of Early Posttransplant Complications and Clinical Outcomes in Kidney Transplant Recipients Aged ≥65 y.Transplantation direct · 2026Article
- Impact of pretransplant donor-specific antibodies and human leukocyte antigen mismatches on graft and patient outcomes: A cohort from Saudi Arabia.World journal of transplantation · 2026Article
- Measuring or estimating glomerular filtration rate in potential kidney donors: a comparative study.Clinical kidney journal · 2026Article
- Back-Table Repair of Parenchymal and Collecting System Injury of a Living Donor Kidney.Cureus · 2026Article
- Prevalence of Obesity, Comorbidities, and Eligibility for Pre-Transplant Bariatric Surgery in 275 Patients Awaiting Kidney Transplant at a Single Center in Germany.Annals of transplantation · 2026Article
- Transplant House Calls Plus Peer Mentorship: Assessing Impact on Living Donor Kidney Transplant Access and Patient-Reported Outcomes for Black Patients.Journal of racial and ethnic health disparities · 2026Article
- Transplantation and Employment Earnings in Kidney Transplant Recipients.JAMA network open · 2026Article
- Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundMost kidneys for transplantation come from deceased donors, though healthy live individuals may also donate. Living donor transplants generally show better outcomes than deceased donor transplants, but it is unclear whether this reflects inherent benefits of having a living donor kidney or differences in donor and recipient characteristics. Using data from 10 915 UK kidney-only transplants, the aim of this study was to determine the causal effect of living donors on graft survival, considering all-cause death without graft failure as a competing risk.
methodsThis study used inverse probability of treatment weighting based on propensity scores to adjust for imbalances in baseline variables between recipients of living and deceased donor kidneys implanted between 2010 and 2021. The mean treatment effect, had all patients received kidneys from living donors, was estimated from differences in survival probabilities and restricted mean survival time using weighted competing risks models.
resultsAfter adjustment for key confounders, living donor kidney transplantation (LDKT) was associated with a 6.03% (95% c.i. 4.71% to 7.35%) lower 5-year risk of graft failure compared with deceased donor kidney transplantation (DDKT). Over 7 years, living donor recipients experienced an additional 0.36 (95% c.i. 0.29 to 0.43) years of graft survival. Benefits persisted across clinically relevant LDKT subgroups.
conclusionLDKT is associated with superior graft survival compared with DDKT after adjusting for confounders. Findings highlight the importance of promoting living donor programmes whilst simultaneously identifying opportunities to enhance DDKT. Future work may clarify whether factors such as reduced cold ischaemia time drive these benefits.
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