ArticleAnaesthesia2025
Individual and combined effects of chemical and mechanical power on postoperative pulmonary complications: a secondary analysis of the REPEAT study.
Article in Anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Mechanical power during one-lung ventilation is associated with postoperative pulmonary complications in patients undergoing lobectomy: a single-center prospective cohort study.BMC anesthesiology · 2026Trial
- Airway-derived mechanical power and postoperative pulmonary complications in obese adults undergoing laparoscopic bariatric surgery: a secondary analysis of a randomised trial.Journal of anesthesia · 2026Article
- Optimal oxygenation in the intensive care unit: what recent trials do-and do not-tell us.Acute and critical care · 2026Article
- Intraoperative mechanical power and postoperative pulmonary complications: association and threshold analysis in adult intra-abdominal surgery.Journal of anesthesia, analgesia and critical care · 2026Article
- How to set the ventilator during surgery? Key principles to guide intraoperative mechanical ventilation.Intensive care medicine · 2026Article
- Deconstructing the Role of Mechanical Power in Lung Injury and Respiratory Failure.Anesthesiology · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
introductionIntra-operative supplemental oxygen and mechanical ventilation expose the lungs to potentially injurious energy. This can be quantified as 'chemical power' and 'mechanical power', respectively. In this study, we sought to determine if intra-operative chemical and mechanical power, individually and/or in combination, are associated with postoperative pulmonary complications.
methodsUsing an individual patient data analysis of three randomised clinical trials of intra-operative ventilation, we summarised intra-operative chemical and mechanical power using time-weighted averages. We evaluated the association between intra-operative chemical and mechanical power and a collapsed composite of postoperative pulmonary complications using multivariable logistic regression to estimate the odds ratios related to the effect of 1 J.min
resultsOf 3837 patients recruited to three individual trials, 2492 with full datasets were included in the analysis. Intra-operative time-weighted average (SD) chemical power was 10.2 (3.9) J.min DISCUSSION: Both chemical and mechanical power are independently associated with postoperative pulmonary complications. Further work is required to determine causality.
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