ArticleJournal of Korean medical science2025
Association of Serum Vascular Endothelial Growth Factor-A With Pubertal Stage by Sex and Its Relationship With Precocious Puberty in Girls.
Article in Journal of Korean medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Hypothalamic neuroimmune remodeling as an immunometabolic bridge between childhood obesity and earlier pubertal onset.Frontiers in immunology · 2026Review
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Authors and funding
3 authors.
Funding
Abstract
backgroundVascular endothelial growth factor-A (VEGF-A) is essential for normal growth plate morphogenesis, including blood vessel invasion and cartilage remodeling. We assessed serum VEGF-A levels according to pubertal stage by sex and investigated their relationship with precocious puberty.
methodsOur study included 180 children aged 6-15 years (153 children with normal puberty [92 boys and 61 girls] and 27 girls with precocious puberty). Clinical and biochemical characteristics according to prepubertal stages were compared in boys and girls, respectively. Serum VEGF-A and leptin levels were performed across Tanner stages.
resultsMean VEGF-A levels were similar among boys and girls with normal puberty (433.7 ± 326.1 pg/mL vs. 483.9 ± 390.5 pg/mL). There was no significant difference in the VEGF-A levels between prepubertal and pubertal boys. VEGF-A levels were significantly higher in pubertal girls than in prepubertal girls (595.9 ± 405.4 pg/mL vs. 264.2 ± 138.0 pg/mL,
conclusionOur study showed sex-related differences in VEGF-A levels according to the pubertal stage. Therefore, VEGF-A may be involved in the progression of precocious puberty.
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