ArticleInternational journal of ophthalmology2025
Nanopore targeted sequencing identifies pathogens in patients with postoperative endophthalmitis.
Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimTo estimate if nanopore targeted sequencing (NTS) could identify pathogens causing postoperative endophthalmitis and further determine the feasibility of clinical application of NTS.
methodsA total of 55 patients (55 eyes) with postoperative endophthalmitis were retrospectively included in this study with their medical records. Intraocular fluid samples were examined by NTS and microbial culture. All included patients had undergone examinations including measurement of best corrected visual acuity (BCVA) and intraocular pressure (IOP), slit-lamp biomicroscopy, and indirect ophthalmoscopy; additionally, they underwent B-ultrasound, anterior segment photography, and fundus photography if necessary.
resultsAmong 55 patients with postoperative endophthalmitis, the age was 65.25±15.04y and there were 30 female (54.54%) patients. Forty-one (74.54%) vitreous humor samples and fourteen (25.45%) aqueous humor samples were sent for both NTS and microbial culture. NTS had a notable higher detection rate than microbial culture in detecting pathogens (90.91%
conclusionNTS can provide rapid identification and highly sensitive detection of pathogens among patients with postoperative endophthalmitis, which can guide anti-infection treatment and improve visual prognosis.
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