Evidence map›Paper›PMID 40827292›Full record

ArticleInternational journal of ophthalmology2025

Systemic C-reactive protein levels in patients with geographic atrophy stratified by sex.

Ramya Gnanaraj, Alan G Palestine, Brandie D Wagner, Jennifer L Patnaik, Talisa E de Carlo Forest, Marc T Mathias, Niranjan Manoharan, Vivian Rajeswaren, Naresh Mandava, Anne M Lynch

Abstract read
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In one paragraph

Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ramya GnanarajDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Alan G PalestineDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Brandie D WagnerColorado School of Public Health, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Jennifer L PatnaikDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Talisa E de Carlo ForestDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Marc T MathiasDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Niranjan ManoharanDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Vivian RajeswarenDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Naresh MandavaDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Anne M LynchDepartment of Ophthalmology, University of Colorado School of Medicine, Aurora, CO 80045, USA.

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
Biomarkers of Systemic Inflammation in Intermediate Age-Related Macular DegenerationR01EY032456 · NEI · UNIVERSITY OF COLORADO DENVER · PI LYNCH, ANNE M. · 2021 to 2024
$1.6M
NCATS NIH HHS UL1 TR002535NEI NIH HHS R01 EY032456
6 · The paper itself

Abstract

aimTo determine the differences in levels of systemic C-reactive protein (CRP) in patients with geographic atrophy (GA) and sex-based differences in CRP levels.

methodsBlood samples from patients with GA and controls were collected in a prospective age-related macular degeneration (AMD) registry from August 2014 to June 2021. AMD was confirmed using multimodal imaging and the Beckman and Consensus of Atrophy Meeting criteria for GA. High-sensitivity serum CRP levels were measured using an automated nephelometer. A non-parametric (rank-based) linear regression model was fit with an interaction between sex and GA.

resultsThere were 97 GA patients and 139 controls, with females comprising 55% and 66% of each cohort, respectively. There is no difference in CRP between cases and controls, with a median (interquartile range) of 1.2 (0.6-2.6) mg/L in GA patients versus 1.3 (0.8-2.9) mg/L in controls (

conclusionThere is no significant difference in systemic CRP levels between GA cases and controls.

Indexed as

age-related macular degenerationC-reactive proteingeographic atrophymultimodal retinal imaging

Identifiers

PMID40827292
PMCPMC12311458

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.