ArticleInternational journal of ophthalmology2025
Choroidal response to optical defocus as a potential surrogate marker for myopia control effect.
Article in International journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative effectiveness of outdoor and exercise interventions for myopia control in children and adolescents: a systematic review and network meta-analysis of randomized clinical trials.Frontiers in public health · 2026Pooled it
- Subfoveal Choroidal Thickness is Independently Associated with Axial Length and Myopia in Preschool Children: A Swept-Source Optical Coherence Tomography Study.Ophthalmology and therapy · 2026Article
- Impact of Myopia Control Interventions on Choroidal Thickness in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Ophthalmology science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate short-term changes in choroidal thickness in response to peripheral myopic defocus induced by two designs of multifocal corneal gas permeable contact lenses (MFGPCL) in young adults.
methodsSeventeen participants, with a mean age of 24.5±4y, underwent choroidal thickness and vascularity index measurements using enhanced depth imaging optical coherence tomography (EDI OCT) at baseline, one day, and one week following MFGPCL wear. Two center-distance MFGPCL designs with similar center zone diameters of 3.0 mm but different peripheral add powers (low add: +1.5 D and high add: +3.0 D) were tested. Each participant was randomly assigned to wear one of the two MFGPCL designs. Measurements of total, luminal, and stromal choroid thickness were obtained in five eccentric regions (6 mm towards the periphery) in all quadrants.
resultsSignificant thickening in total choroidal thickness were observed after one week of wearing both high add (+10±6 µm) and low add (+7±5 µm) MFGPCLs, with no statistically significant difference between the two groups (
conclusionPeripheral myopic defocus induced by MFGPCLs lead to significant choroidal thickening, including total, luminal, and stromal components. This study highlights the need for future research to explore the dose-response relationship between peripheral myopic defocus and choroidal thickening, utilizing choroidal response as a potential biomarker.
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Registered trials
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