ArticleInfection and drug resistance2025
Distinctive Immuno-Inflammatory Pattern in Tuberculous Lymphadenitis: A Retrospective Cohort Study with Propensity Score Matching.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Immune-inflammatory profiles and disease severity in pulmonary tuberculosis complicated by central nervous system tuberculosis.Frontiers in cellular and infection microbiology · 2026Article
- Age-Stratified Effects of Diabetes Mellitus on Central Nervous System Tuberculosis Risk and Combined Effects with Neutrophil-to-Lymphocyte Ratio.Infection and drug resistance · 2026Article
- Age-stratified immune characteristics in central nervous system tuberculosis patients: a comparative T lymphocyte subset analysis within a cohort of 862 extrapulmonary tuberculosis patients.BMC infectious diseases · 2025Article
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Authors and funding
7 authors.
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Abstract
Purpose: Tuberculous lymphadenitis (TBL) represents a common form of extrapulmonary tuberculosis (EPTB), yet its immunological characteristics compared to other EPTB forms remain poorly characterized. We aimed to compare immunological parameters between TBL and non-TBL patients to elucidate site-specific immune phenotypes. Patients and Methods: We conducted a retrospective single-center study at Fuzhou Pulmonary Hospital, China (April 2018-April 2024). From 1,408 EPTB patients screened, 862 met inclusion criteria after excluding immunocompromised patients, those with incomplete data, or age <18 years. Patients were stratified into TBL (n=337) and non-TBL EPTB (n=525) groups. To mitigate confounding, we implemented 1:1 propensity score matching based on demographic factors (age, sex) and nutritional status (BMI, hemoglobin, albumin), yielding 323 matched pairs. We compared inflammatory markers (neutrophil count, neutrophil-to-lymphocyte ratio [NLR]) and immunological parameters (lymphocyte count and T lymphocyte subsets: CD3+, CD4+, CD8+, CD45+) between groups using Mann-Whitney Results: In matched cohorts, TBL patients demonstrated markedly higher lymphocyte counts than non-TBL patients (1.27 vs 1.04×10 Conclusion: TBL patients exhibit distinctive immunological characteristics, including lower NLR values and elevated T lymphocyte subset counts compared to other EPTB forms. These findings provide novel insights into site-specific immune responses to Mycobacterium tuberculosis infection, enhancing our understanding of the pathophysiological mechanisms underlying different manifestations of tuberculosis.
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