ReviewJournal of pain research2025
Borneol's Pre-Clinical Analgesic Efficacy: Mediated by Receptor and Immune Mechanisms.
Review in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic pain affects over 10% of the global population, yet current analgesics face limitations such as addiction and systemic toxicity. Borneol, a traditional Chinese medicine (TCM) with over a millennium history, has emerged as a promising alternative due to its multi-target mechanisms. This review synthesizes preclinical evidence demonstrating borneol's dual analgesic pathways: (1) receptor-mediated actions (eg, TRPM8 activation, GABA agonism) and (2) immune modulation (eg, NF-κB suppression, ROS inhibition). Notably, comparative analysis with menthol reveals borneol's superior TRPM8 specificity and lack of opioid-related side effects. By elucidating these mechanisms, we advocate for borneol's integration into modern pain management strategies, highlighting its potential as a safe, multi-modal therapeutic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.