ArticleNature and science of sleep2025
Association Between Soy Product Intake and Insomnia in Chinese Middle-Aged and Older Adults: A Cross-Sectional Study.
Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Objective: Insomnia has various adverse effects on middle-aged and older adults. Improving insomnia by adjusting diet has attracted attention. This study investigated the relationship between soy product intake and insomnia in middle-aged and older adults and explored the role of inflammatory factors. Methods: The study included 877 middle-aged and older adults aged ≥45 years which from general patients who made an appointment or were admitted to the cardiology department at Wenling Hospital in Taizhou City. The proportion of female participants is 35.01%. Soy product intake was assessed using the Food Frequency Questionnaire (FFQ), sleep was quantified using the Insomnia Severity Index (ISI). The median (IQR) of soy product intake is ≤1 time per week (≤1 time per week, 2-6 times per week) and the mean/SD value of insomnia score is 5.43/5.13. Results: In Chinese middle-aged and older adults, soy product intake was negatively correlated with insomnia (|r|s ≥ 0.117, ps < 0.001), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and triglyceride (TG) levels (adjusted β: -0.139, 95% CI: -0.265 to -0.012; β: -0.049, 95% CI: -0.091 to -0.006; β: -0.043, 95% CI: -0.085 to -0, respectively). There was no significant correlation between soy product intake and White Blood Cell (WBC), Absolute Neutrophil Count (GRAM), Platelet Count (PLT), Interleukin-1β (IL-1β), Interleukin-2 (IL-2), Interleukin-6 (IL-6), Hemoglobin (Hb), Red Blood Cell (RBC), Low-Density Lipoprotein Cholesterol (LDL-C), High-Density Lipoprotein Cholesterol (HDL-C) and Total Cholesterol (TC) levels. Conclusion: Lower levels of soy product intake are associated with higher rates of insomnia in the middle-aged and older adults. Additionally, soy product intake is negatively correlated with peripheral blood CRP, TNF-α and TG levels. This study provides a new clinical perspective for middle-aged and older adults to enhance sleep through a balanced diet, wherein the inflammation and lipid may play a potentially crucial role.
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