ArticlePatient preference and adherence2025
Impact of Primary Chronic Immune Thrombocytopenia and Thrombopoietin Receptor Agonists Treatment Instructions on Daily Living: Results of a Multinational Cross-Sectional Survey.
Article in Patient preference and adherence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Real-world experiences with subcutaneous therapy in adults with primary immune thrombocytopenia: A dual cross-sectional survey study of patients and clinicians in Italy.Therapeutic advances in hematology · 2026Article
- Efficacy and Safety of Avatrombopag Treatment in Immune Thrombocytopenia Patients in Poland: A Multicenter Study.TH open : companion journal to thrombosis and haemostasis · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Thrombopoietin receptor agonists (TPO-RAs) are second-line treatments for people with immune thrombocytopenia (ITP). A survey was conducted to evaluate the understanding of and adherence to TPO-RA treatment instructions, and to determine the impact of ITP and TPO-RAs on daily living. Patients and Methods: Cross-sectional, self-administered, online survey conducted from September 2023 to April 2024. Respondents were aged ≥18 years, diagnosed with primary chronic ITP, and prescribed a TPO-RA in the last 12 months and for ≥3 months. Results: In total, 221 respondents were voluntarily recruited by patient organizations and completed the survey. Over one-third (37%) of respondents were given ≥5 specific instructions on medication use (eltrombopag 58%; avatrombopag 24%; romiplostim 9%). Taking treatment at the same time each day/week was most common. Eltrombopag-treated respondents were given the most instructions about food: timing of medication relative to meals (72%), timing of meals relative to medication (65%), and the restriction (44%) or avoidance (69%) of certain foods. Despite this, nearly one-third (32%) of eltrombopag-treated respondents ate when/what they wanted at times, and 64% would prefer to have a TPO-RA with no food/drink restrictions. Compared to before ITP diagnosis, living with ITP negatively impacted ≥1 daily activity or mental health in 89% of respondents, most commonly travelling (for pleasure [69%]). Approximately one-third (36%) experienced an improvement or no change in ≥1 daily activity or mental health after TPO-RA treatment initiation. Eating habits, sleeping, exercise/sport and mental health were markedly worsened by treatment with a TPO-RA. Avatrombopag and eltrombopag had the highest rates of any reported improvements across daily activities/mental health. Conclusion: This real-world international survey showed that people with ITP may experience a negative impact on their daily activities and mental health from their condition. Treatment with some TPO-RAs may also impair specific activities, likely influenced by administration routes and dietary restrictions.
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