ArticleCureus2025
A Rare Occurrence of Amoxicillin-Induced Aseptic Meningitis in a Young Adult: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aseptic meningitis (AM) is characterized by clinical manifestations and laboratory findings indicative of meningeal inflammation, without detectable bacterial pathogens in routine cultures. Drug-induced aseptic meningitis (DIAM) is a rare but important etiology. It has been associated with certain drugs, including intravenous immunoglobulin, antiepileptic drugs, monoclonal antibodies, and antibiotics. Amoxicillin-induced aseptic meningitis (AIAM) is an exceptionally rare variant. We present a case of a 25-year-old female who presented with fever and cough for five days. She was prescribed amoxicillin by her general practitioner (GP) and continued the course for five days. Following this, she began to have severe headaches associated with neck stiffness and photophobia. An urgent lumbar puncture (LP) was conducted, and then a combination of intravenous cephalosporins and acyclovir was started empirically, with a differential diagnosis of partially treated meningitis, possibly bacterial in origin. Cerebrospinal fluid (CSF) analysis revealed lymphocytic pleocytosis with low protein and normal glucose levels. Both bacterial and fungal cultures were negative. Subsequently, herpes simplex virus infection was ruled out through serological testing. Hence, the antibiotics and antivirals were stopped, and she was initiated on symptomatic management. The patient recalled a similar episode occurring subsequent to the administration of amoxicillin for a respiratory infection, a detail that was also reflected in her medical records. Considering her clinical presentation, CSF findings, and the previous exposure to amoxicillin coinciding with an episode of meningitis, a multidisciplinary team (MDT) involving Neurology proposed AIAM as a likely diagnosis. Furthermore, her rapid recovery following the cessation of the drug confirmed the final diagnosis of AIAM. This case emphasizes the need for early recognition to avoid unnecessary antimicrobial treatment, as well as recognizing AIAM in a patient, which can prevent recurrent occurrences.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.