ReviewCureus2025
Clinical and Radiographic Evaluation of Biodentine for Apexogenesis in Young Permanent Mandibular Molars: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Regenerative Potential of Biodentine in Complex Endodontic Conditions: A Systematic Review of Clinical and Radiological Evidence.Medicina (Kaunas, Lithuania) · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apexogenesis, a vital pulp therapy, is a crucial treatment option for preserving the vitality of immature permanent teeth affected by caries or trauma. The goal of apexogenesis is to promote the continued development of the root and apex, allowing for a more favorable prognosis. This systematic review and meta-analysis aimed to evaluate the clinical and radiographic outcomes of Biodentine (Septodont, Saint-Maur-des-Fossés, France) for apexogenesis in young permanent mandibular molars. The protocol of the present article was registered in the PROSPERO database and allocated the identification number CRD42024589204. A comprehensive search of PubMed, Scopus, and EMBASE was conducted using a combination of Boolean operators (AND, OR) and Medical Subject Headings (MeSH) keywords to retrieve relevant studies in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The formulated population, intervention, comparison, and outcome (PICO) question was "What are the clinical and radiographic outcomes for apexogenesis in young permanent mandibular molars?" Six trials were considered for inclusion, with the studies demonstrating that Biodentine could be used in stepwise root canal retreatment with/without coronal seal and indirect pulp treatment. However, the studies also highlighted the importance of individual clinical circumstances and preference in choosing the treatment material. The meta-analysis revealed that Biodentine tends to present slightly higher clinical success rates compared to other calcium compounds, although the difference was not statistically significant. The heterogeneity test revealed moderate variability between studies. Regarding radiographic success rates, the analysis showed that Biodentine tends to have similar radiographic success rates compared to mineral trioxide aggregate (MTA) at six-month and one-year follow-up periods. The overall summary estimate revealed no significant difference between Biodentine and MTA. The heterogeneity test did not detect significant variability between studies at both follow-up periods. Our systematic review suggests that Biodentine has similar clinical and radiographic success rates compared to other calcium compounds and MTA for apexogenesis in young permanent mandibular molars. However, the results should be interpreted with caution due to the moderate heterogeneity and the limited number of studies included.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.