ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Lower odor identification in subjective cognitive decline: a meta-analysis.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Single odor identification in subjective cognitive decline, mild cognitive impairment and Alzheimer's dementia.Wiener klinische Wochenschrift · 2026Article
- Color-modulated olfactory testing using RAPPIT: An innovative tool for early detection of cognitive decline.Journal of Alzheimer's disease : JAD · 2026Article
- Subjective and objective olfactory dysfunction and its screening value in patients with subjective cognitive decline, mild cognitive impairment, and Alzheimer's dementia.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026Article
- Alzheimer's disease and cerebrovascular biomarkers in relation to odor identification in a naturalistic clinical cohort.Alzheimer's research & therapy · 2026Article
- Olfactory decline tracks central-to-peripheral spread of tau pathology in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Olfactory Testing With Focus on Odor Identification for Early Detection of Alzheimer's Disease in Mild Cognitive Impairment.American journal of Alzheimer's disease and other dementiasReview
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Abstract
introductionOdor identification correlates with Alzheimer's disease (AD) biomarkers, and its decline may emerge before measurable cognitive deficits - as early as the subjective cognitive decline (SCD) stage. We aimed to compare odor identification between SCD and cognitively normal (CN) stages.
methodsA systematic search of four databases identified studies assessing olfactory identification and cognitive screening in individuals aged 50+. A random-effects meta-analysis was performed on 11 studies (660 SCD, 574 CN).
resultsIndividuals with SCD exhibited lower olfactory identification scores compared to CN participants (SMD = -0.67, 95% CI [-1.31, -0.03], DISCUSSION: Odor identification is lower in pre-mild cognitive impairment individuals reporting SCD. Olfactory decline may emerge prior to measurable general cognitive decline, supporting its role as a screen for AD. Highlights: Individuals with SCD exhibit lower odor identification scores.Olfactory identification may serve as an early marker of neurodegeneration in preclinical AD.Heterogeneity highlights the need for multimodal biomarker approaches.
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