Trial reportPhysiological reports2025
Effect of sodium balance on levels of nitrates in healthy subjects: Posthoc analysis of a randomized, double-blinded, placebo-controlled, crossover study.
Trial report in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06968182 (The Effect of Sodium on Erythrocyte Salt Sensitivity, Syndecan-1 and Heparin Sulfate in Healthy Subjects), which is not on this map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Sodium on Erythrocyte Salt Sensitivity, Syndecan-1 and Heparin Sulfate in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled, Cross-Over Study
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Nitric oxide (NO) regulates renal sodium handling, but the relationship between sodium intake, NO synthesis, and nitrate/nitrite levels is unclear in humans. In a randomized, placebo-controlled, double-blinded, crossover study, 27 healthy subjects followed a 4-day low-sodium diet with either sodium chloride tablets or placebo daily, separated by a 3-week washout. Blood pressure, pulse wave velocity, and glomerular filtration rate were assessed. Blood and 24-h urine samples were analyzed for nitrate, nitrite, cyclic guanosine monophosphate (cGMP), and electrolytes. Plasma nitrate levels were lower after high sodium intake (p = 0.019), while plasma nitrite and cGMP levels remained unchanged. Urinary excretion of nitrate and nitrite did not differ, but nitrate clearance and fractional excretion increased (both p = 0.010). Renal handling of nitrite was unchanged. No significant differences were observed in blood pressure, pulse wave velocity, or glomerular filtration rate. When stratified by sex, females showed higher plasma nitrate after low sodium and a decrease after high sodium. Females decreased urinary nitrate excretion, whereas males remained stable. In conclusion, high sodium intake decreased plasma nitrate without increased excretion, suggesting greater nitrate utilization, particularly in females. ClinicalTrials.gov Identifier: NCT06968182.
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Registered trials
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