ArticleJournal of cell science2025
Microtubules regulate tissue-level navigation in skin-resident macrophages.
Article in Journal of cell science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Revealing the Diagnostic Potential of Three RHO GTPase-Related Genes in Osteoarthritis Based on Single-Cell RNA Sequencing and GEO Dataset Analysis.International journal of genomics · 2026Article
- Mechanisms and therapeutic insights from zebrafish models of wound healing.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
- Update of
Authors and funding
6 authors.
Funding
Abstract
Immune cells rapidly respond to tissue damage through dynamic properties of the cytoskeleton. How microtubules control immune cell functions during injury responses remains poorly understood. Within skin, tissue-resident macrophages known as Langerhans cells use dynamic dendrites to surveil the epidermis for damage and migrate through a densely packed epithelium to wounds. Here, we used Langerhans cells within the adult zebrafish epidermis as a model to investigate roles of microtubules in immune cell tissue surveillance, phagocytosis and directed migration. We describe microtubule organization within Langerhans cells and show that depolymerizing the microtubule cytoskeleton alters dendrite morphology, debris engulfment and migration efficiency. We found that the microtubule organizing center positions adjacent to engulfed debris and that its position correlates with navigational pathfinding during tissue-level migration. Stabilizing microtubules inhibits Langerhans cell motility during directed cell migration by impairing navigation around cellular obstacles. Collectively, our work demonstrates requirements for microtubules in the dynamic actions of tissue-resident macrophages during epithelial surveillance and wound repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.