Evidence map›Paper›PMID 40827034›Full record

ReviewScience progress

Oxidative stress and programmed cell death in diabetic wounds: A comprehensive review.

Lue Hong, Miaofu Li, Yunpeng Fan

Abstract readReview
In one paragraph

Review in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Special Issue "Recent Advances in Wound Healing: 2nd Edition".International journal of molecular sciences · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Kuwanon A fromAntioxidants (Basel, Switzerland) · 2026
    Article
  8. Review
  9. Shikonin and CoFrontiers in chemistry · 2026
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lue HongZhejiang Chinese Medical University, Hangzhou, China.
Miaofu LiDepartment of Cardiology, Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yunpeng FanDepartment of Orthopaedics, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.ORCID 0009-0005-3687-6463

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic wounds, a prevalent and severe complication of diabetes, pose a significant burden on the global healthcare system. This burden arises from their high incidence, high disability rates, and substantial treatment costs. Research has shown that excessive oxidative stress damage plays a crucial role in diabetic wounds. This oxidative stress not only complicates the healing process but also triggers various forms of programmed cell death, such as apoptosis, pyroptosis, necrosis, and ferroptosis. These programmed cell deaths significantly hinder wound recovery. In this narrative review, we comprehensively review the impact of oxidative stress on diabetic wounds and its intricate interplay with programmed cell death. With ongoing intensive research into oxidative stress in diabetic wounds, we are confident that innovative therapies will emerge in the near future.

Indexed as

ApoptosisDiabetes ComplicationsDiabetes MellitusOxidative StressWound HealingAnimalsFerroptosisHumansNecrosisPyroptosisReactive Oxygen SpeciesReactive Oxygen SpeciesDiabetic woundoxidative stressprogrammed cell death

Identifiers

PMID40827034
PMCPMC12365470

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.